A case of eosinophilic annular erythema

Eosinophilic annular erythema (EAE) is a rare, recurrent disease of unknown etiology with tissue eosinophilia that was initially reported in a pediatric patient. It is debatable whether EAE is a distinct disease entity or a subtype of Well's syndrome. Clinically, EAE is characterized by annular erythematous plaques lasting for 4 to 12 months that predominantly affect the trunk and proximal extremities. Histologically, dense superficial and deep perivascular inflammatory infiltrates composed of lymphocytes and abundant eosinophils are observed. Herein, we report a case of EAE in a 21-year-old Korean female. The patient visited our clinic with a 1-year history of multiple erythematous annular patches on both legs that became worse during the summer and between seasons. Histopathologic examination demonstrated superficial and deep perivascular, periadnexal, and interstitial infiltrates of lymphocytes and eosinophils in the dermis and the subcutaneous fat layer. Based on the clinical and histological features, the case was diagnosed as eosinophilic annular erythema.