TY - JOUR
T1 - A case of gastric cancer metastasis to the breast in a female with BRCA2 germline mutation and literature review
AU - Dulskas, Audrius
AU - Al Bandar, Mahdi
AU - Choi, Yoon Young
AU - Shin, Su Jin
AU - Beom, Seung Hoon
AU - Son, Taeil
AU - Kim, Hyung Il
AU - Cheong, Jae Ho
AU - Hyung, Woo Jin
AU - Noh, Sung Hoon
N1 - Publisher Copyright:
© 2017, © 2017 The Royal Belgian Society for Surgery.
PY - 2019/1/2
Y1 - 2019/1/2
N2 - Introduction: Gastric cancer is a deadly disease. Common sites of distant metastasis of gastric cancer are the peritoneum, liver, lymph nodes, and lung. The breast is a rare site of metastasis in gastric cancer which occurs in males dominantly. Patients and methods: Here, we report the first case of metastatic gastric cancer to the breast in a patient with the breast cancer 2 (BRCA2) germline mutation. A 34-year-old female was admitted to the hospital with dyspepsia and a palpable mass in the left breast. Gastric cancer was confirmed to be signet ring cell adenocarcinoma. The breast mass exhibited histological properties consistent with gastric cancer. Immunohistochemistry results showed the breast tumor was CDX-2 and CK20-positive, but ER-, CK7-, and GATA3-negative. The BRCA1 gene had a wild-type sequence, but a heterozygous variant was discovered in BRCA2 in exon 10 (c.1744A > C, p.T582P); the significance of this variant is unknown. Results: The patient received palliative XELOX (capecitabine + oxaliplatin) with radiation therapy to the stomach. The breast tumor resolved completely, but the overall response was partial. Conclusion: Gastric cancer metastasis to the breast is rare, but should be considered in young female patients with signet ring cell type gastric cancer.
AB - Introduction: Gastric cancer is a deadly disease. Common sites of distant metastasis of gastric cancer are the peritoneum, liver, lymph nodes, and lung. The breast is a rare site of metastasis in gastric cancer which occurs in males dominantly. Patients and methods: Here, we report the first case of metastatic gastric cancer to the breast in a patient with the breast cancer 2 (BRCA2) germline mutation. A 34-year-old female was admitted to the hospital with dyspepsia and a palpable mass in the left breast. Gastric cancer was confirmed to be signet ring cell adenocarcinoma. The breast mass exhibited histological properties consistent with gastric cancer. Immunohistochemistry results showed the breast tumor was CDX-2 and CK20-positive, but ER-, CK7-, and GATA3-negative. The BRCA1 gene had a wild-type sequence, but a heterozygous variant was discovered in BRCA2 in exon 10 (c.1744A > C, p.T582P); the significance of this variant is unknown. Results: The patient received palliative XELOX (capecitabine + oxaliplatin) with radiation therapy to the stomach. The breast tumor resolved completely, but the overall response was partial. Conclusion: Gastric cancer metastasis to the breast is rare, but should be considered in young female patients with signet ring cell type gastric cancer.
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U2 - 10.1080/00015458.2017.1411554
DO - 10.1080/00015458.2017.1411554
M3 - Article
C2 - 29202657
AN - SCOPUS:85036638704
VL - 119
SP - 59
EP - 63
JO - Acta Chirurgica Belgica
JF - Acta Chirurgica Belgica
SN - 0001-5458
IS - 1
ER -
