A case of immunoglobulin a pemphigus: Intraepidermal neutrophilic dermatosis type

Ji Hye Heo, Hee Seong Yoon, Si Hyub Lee, Seung Dohn Yeom, Lucia Kim, Soo Chan Kim, Ji Won Byun, Jeonghyun Shin, Gwang Seong Choi

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1 Citation (Scopus)


Immunoglobulin A (IgA) pemphigus is a rare variant of an autoimmune bullous disease with IgA antibodies. IgA pemphigus is divided into 2 major subtypes: The subcorneal pustular dermatosis (SPD) type and intraepidermal neutrophilic (IEN) dermatosis type. We documented a case of an 18-year-old woman with recurrent generalized blisters and pustules that were especially severe in the intertriginous areas. Some half-and-half blisters and coalesced pustules in an annular pattern with crusts were simultaneously observed. A biopsy specimen from one of the half- A nd-half blister lesions showed intraepidermal separation with multiple neutrophils. Direct immunofluorescence staining revealed lace-like intercellular deposition of IgA in the entire epidermis. IgA antibody deposits were also observed in the patient's serum. The eruptions cleared with systemic steroids and colchicine 0.6 mg for 1 week, and the patient remained in partial remission at the 8-month follow-up. Herein, we report a case of IEN-type IgA pemphigus, clinically mimicking SPD with half-and-half blisters. (Korean J Dermatol 2019;57(8):492-495).

Original languageEnglish
Pages (from-to)492-495
Number of pages4
JournalKorean Journal of Dermatology
Issue number8
Publication statusPublished - 2019 Sept

Bibliographical note

Publisher Copyright:
© 2019 Korean Dermatological Association. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Dermatology


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