A case of intraoperative anaphylaxis caused by bovine-derived thrombin

Hye Jung Park, Kyung Soo Suk, Jung Won Park

Research output: Contribution to journalLetter

Abstract

Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized. Skin test and specific immunoglobulin E test showed positive results for bovine thrombin and beef, respectively. During the second stage of operation (After 10 days from first stage of operation), bovine-derived thrombin powder was excluded and the operation was successful without any unexpected events. Therefore, bovine thrombin should be used with caution because it might cause anaphylaxis.

Original languageEnglish
Pages (from-to)184-186
Number of pages3
JournalAllergy, Asthma and Immunology Research
Volume10
Issue number2
DOIs
Publication statusPublished - 2018 Mar 1

Fingerprint

Anaphylaxis
Thrombin
Powders
Absorbable Gelatin Sponge
Intervertebral Disc Displacement
Angioedema
Spinal Cord Diseases
Urticaria
Hemostatics
Exanthema
Skin Tests
Hemostasis
Intravenous Infusions
Immunoglobulin E
Orthopedics
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

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abstract = "Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized. Skin test and specific immunoglobulin E test showed positive results for bovine thrombin and beef, respectively. During the second stage of operation (After 10 days from first stage of operation), bovine-derived thrombin powder was excluded and the operation was successful without any unexpected events. Therefore, bovine thrombin should be used with caution because it might cause anaphylaxis.",
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A case of intraoperative anaphylaxis caused by bovine-derived thrombin. / Park, Hye Jung; Suk, Kyung Soo; Park, Jung Won.

In: Allergy, Asthma and Immunology Research, Vol. 10, No. 2, 01.03.2018, p. 184-186.

Research output: Contribution to journalLetter

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