A case of isolated metastatic hepatocellular carcinoma arising from the pelvic bone.

Kyu Sik Jung, Kyeong Hye Park, Young Eun Chon, S. R. Lee, Young Nyun Park, Do Yun Lee, Jinsil Seong, Junyong Park

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Reports of metastatic hepatocellular carcinoma (HCC) without a primary liver tumor are rare. Here we present a case of isolated HCC that had metastasized to the pelvic bone without a primary focus. A 73-year-old man presented with severe back and right-leg pain. Radiological examinations, including computed tomography (CT) and magnetic resonance imaging (MRI), revealed a huge mass on the pelvic bone (13×10 cm). He underwent an incisional biopsy, and the results of the subsequent histological examination were consistent with metastatic hepatocellular carcinoma. The tumor cells were positive for cytokeratin (AE1/AE3), hepatocyte paraffin 1, and glypican-3, and negative for CD56, chromogranin A, and synaptophysin on immunohistochemical staining. Examination of the liver by CT, MRI, positron-emission tomography scan, and angiography produced no evidence of a primary tumor. Radiotherapy and transarterial chemoembolization were performed on the pelvic bone, followed by systemic chemotherapy. These combination treatments resulted in tumor regression with necrotic changes. However, multiple lung metastases developed 1 year after the treatment, and the patient was treated with additional systemic chemotherapy.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalThe Korean journal of hepatology
Volume18
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Pelvic Bones
Hepatocellular Carcinoma
Neoplasms
Glypicans
Tomography
Magnetic Resonance Imaging
Drug Therapy
Chromogranin A
Synaptophysin
Liver
Keratins
Positron-Emission Tomography
Paraffin
Hepatocytes
Leg
Angiography
Radiotherapy
Staining and Labeling
Neoplasm Metastasis
Biopsy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jung, Kyu Sik ; Park, Kyeong Hye ; Chon, Young Eun ; Lee, S. R. ; Park, Young Nyun ; Lee, Do Yun ; Seong, Jinsil ; Park, Junyong. / A case of isolated metastatic hepatocellular carcinoma arising from the pelvic bone. In: The Korean journal of hepatology. 2012 ; Vol. 18, No. 1. pp. 89-93.
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A case of isolated metastatic hepatocellular carcinoma arising from the pelvic bone. / Jung, Kyu Sik; Park, Kyeong Hye; Chon, Young Eun; Lee, S. R.; Park, Young Nyun; Lee, Do Yun; Seong, Jinsil; Park, Junyong.

In: The Korean journal of hepatology, Vol. 18, No. 1, 01.01.2012, p. 89-93.

Research output: Contribution to journalArticle

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