A case of levofloxacin-induced anaphylaxis with elevated serum tryptase levels

I. Ho Lee, Won Yeon Lee, Suk Joong Yong, Kye Chul Shin, Myoung Kyu Lee, Chong Whan Kim, Sang Ha Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Levofloxacin, a fluoroquinolone and L-isomer of the racemate ofloxacin, has been approved for the treatment of acute and chronic bacterial infections. Gastrointestinal complaints are the most frequently reported adverse drug reactions to fluoroquinolones. Other adverse events include headache, dizziness, increased liver enzyme levels, photosensitivity, tachycardia, QT prolongation, and eruptions. Anaphylaxis has been documented as a rare adverse drug reaction to levofloxacin; however, diagnostic tests are needed to evaluate whether these reactions are the result of levofloxacin treatment. While the results of skin tests are considered unreliable due to false-positive responses, the oral provocation test is currently considered to be the most reliable test. Tryptase, a neutral protease, is the dominant protein component of secretory granules in human mast cells, and an increased serum concentration of tryptase is a highly sensitive indicator of anaphylaxis. Herein, we report a case of levofloxacin-induced anaphylaxis in which the patient exhibited elevated serum tryptase levels and a positive oral levofloxacin challenge test result. As anaphylaxis is potentially life-threatening, the administration of fluoroquinolones to patients who have experienced a prior reaction to this type of agent should be avoided.

Original languageEnglish
Pages (from-to)113-115
Number of pages3
JournalAllergy, Asthma and Immunology Research
Volume5
Issue number2
DOIs
Publication statusPublished - 2013 Mar

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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