A case of membranous nephropathy as a manifestation of graft-versus-host disease

Jae Hyun Han, Hyoung Rae Kim, Gi Jeong Kim, Beom Jin Lim, Hyeon Joo Jeong, Hyung Jung Oh, TaeHyun Yoo, Shin-Wook Kang, Kyu Hun Choi, SeungHyeok Han

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT from her human leukocyte antigen-identical brother following myeloablative conditioning chemotherapy. NS occurred 21 months after HSCT without any concurrent features of chronic GVHD. The patient was treated with prednisolone and cyclosporine after renal biopsy confirmed membranous nephropathy, and achieved complete remission. Our report contradicts previous assumptions that concomitant chronic GVHD is responsible for the development of NS, suggesting that NS can develop as a new, independent manifestation of GVHD.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalKidney Research and Clinical Practice
Volume32
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Membranous Glomerulonephritis
Hematopoietic Stem Cell Transplantation
Nephrotic Syndrome
Graft vs Host Disease
Aplastic Anemia
HLA Antigens
Prednisolone
Cyclosporine
Siblings
Kidney
Biopsy
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Cite this

Han, Jae Hyun ; Kim, Hyoung Rae ; Kim, Gi Jeong ; Lim, Beom Jin ; Jeong, Hyeon Joo ; Oh, Hyung Jung ; Yoo, TaeHyun ; Kang, Shin-Wook ; Choi, Kyu Hun ; Han, SeungHyeok. / A case of membranous nephropathy as a manifestation of graft-versus-host disease. In: Kidney Research and Clinical Practice. 2013 ; Vol. 32, No. 1. pp. 39-42.
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A case of membranous nephropathy as a manifestation of graft-versus-host disease. / Han, Jae Hyun; Kim, Hyoung Rae; Kim, Gi Jeong; Lim, Beom Jin; Jeong, Hyeon Joo; Oh, Hyung Jung; Yoo, TaeHyun; Kang, Shin-Wook; Choi, Kyu Hun; Han, SeungHyeok.

In: Kidney Research and Clinical Practice, Vol. 32, No. 1, 01.01.2013, p. 39-42.

Research output: Contribution to journalArticle

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