A case of membranous nephropathy as a manifestation of graft-versus-host disease

Jae Hyun Han, Hyoung Rae Kim, Gi Jeong Kim, Beom Jin Lim, Hyeon Joo Jeong, Hyung Jung Oh, Tae Hyun Yoo, Shin Wook Kang, Kyu Hun Choi, Seung Hyeok Han

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Abstract

Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT from her human leukocyte antigen-identical brother following myeloablative conditioning chemotherapy. NS occurred 21 months after HSCT without any concurrent features of chronic GVHD. The patient was treated with prednisolone and cyclosporine after renal biopsy confirmed membranous nephropathy, and achieved complete remission. Our report contradicts previous assumptions that concomitant chronic GVHD is responsible for the development of NS, suggesting that NS can develop as a new, independent manifestation of GVHD.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalKidney Research and Clinical Practice
Volume32
Issue number1
DOIs
Publication statusPublished - 2013 Mar

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All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

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