A case of multiple endocrine neoplasia type 1 combined with papillary thyroid carcinoma

Hai Jin Kim, Jong Suk Park, Chul Sik Kim, Eun Seok Kang, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Chul Woo Ahn

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This is the first report of papillary thyroid carcinoma combined with multiple endocrine neoplasia type I (MEN 1) in Korea. MEN1 is a hereditary disease comprising neoplastic disorders such as pituitary, parathyroid and pancreatic neuroendocrine tumor, such as gastrinoma. But papillary thyroid cancer was never regarded as its component before in Korea. Herein we present a 39-year-old woman who manifested typical features of MEN1 with a coincidental papillary thyroid carcinoma. Although the family history of MEN1 was definite, her genetic analysis of DNA had revealed no germline mutation in MEN1 gene locus. Unidentified culprit gene unable us further genetic study to find LOH (loss of heterogeneity) in 11q13, the possible explanation of papillary thyroid carcinoma as a new component of MEN1. As we have first experienced a case of MEN1 combined with papillary thyroid carcinoma in Korea, we report it with the review of literature.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalYonsei medical journal
Volume49
Issue number3
DOIs
Publication statusPublished - 2008 Jun 1

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Multiple Endocrine Neoplasia Type 1
Korea
Gastrinoma
Inborn Genetic Diseases
Neuroendocrine Tumors
Papillary Thyroid cancer
Germ-Line Mutation
Genes
DNA

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Hai Jin ; Park, Jong Suk ; Kim, Chul Sik ; Kang, Eun Seok ; Cha, Bong Soo ; Lim, Sung Kil ; Kim, Kyung Rae ; Lee, Hyun Chul ; Ahn, Chul Woo. / A case of multiple endocrine neoplasia type 1 combined with papillary thyroid carcinoma. In: Yonsei medical journal. 2008 ; Vol. 49, No. 3. pp. 503-506.
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Kim, HJ, Park, JS, Kim, CS, Kang, ES, Cha, BS, Lim, SK, Kim, KR, Lee, HC & Ahn, CW 2008, 'A case of multiple endocrine neoplasia type 1 combined with papillary thyroid carcinoma', Yonsei medical journal, vol. 49, no. 3, pp. 503-506. https://doi.org/10.3349/ymj.2008.49.3.503

A case of multiple endocrine neoplasia type 1 combined with papillary thyroid carcinoma. / Kim, Hai Jin; Park, Jong Suk; Kim, Chul Sik; Kang, Eun Seok; Cha, Bong Soo; Lim, Sung Kil; Kim, Kyung Rae; Lee, Hyun Chul; Ahn, Chul Woo.

In: Yonsei medical journal, Vol. 49, No. 3, 01.06.2008, p. 503-506.

Research output: Contribution to journalArticle

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