A case of oil granuloma developed after application of squalene on both eyelids

J. S. Lee, K. H. Lee, S. I. Chun

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Oil granuloma develops mainly after injection of oil substances such as paraffin, silicone, etc., but there have been reports of oil granuloma after topical application of lipid substance to the body. A 22-year-old woman developed oil granuloma after the application of squalene on both lower eyelids. Histopathologic findings showed acanthosis and dyskeratosis of the hair follicles. Lipid substances staining with oil-red-O stain were found mainly on the hair follicles, and partly on the epidermis. We report a case of oil granuloma caused by squalene that may have penetrated through the hair follicles and partly through the epidermis resulting in chronic granulomatous changes in the dermis.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalKorean Journal of Dermatology
Issue number1
Publication statusPublished - 1995 Jan 1


All Science Journal Classification (ASJC) codes

  • Dermatology

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