Abstract
Osteoclast-like giant cell tumor of the pancreas is a very rare tumor. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may arise from epithelial precursors. This unusual tumor presents in the 6th or 7th decade with a nearly equal gender ratio. Pure forms of osteoclast-like giant cell tumor have a better prognosis because they have a predilection to local spread, are slower to metastasize and rarely metastasize to lymph nodes, but these forms are very rare. We present an osteoclast-like giant cell tumor arising in the body of the pancreas in a 71 year-old male patient. The tumor was composed of two major cell types: atypical mononuclear cells and abundant osteoclast-like multinucleated giant cells. Immunohistochemical studies showed that atypical cells were strongly reactive for vimentin and focally reactive for cytokeratin. In contrast, the giant cells were immunoreactive for CD68, but negative for cytokeratin. Three months later, the tumor size increased and liver metastasis was newly developed. He died at 11 months after the diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 441-445 |
| Number of pages | 5 |
| Journal | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi |
| Volume | 45 |
| Issue number | 6 |
| Publication status | Published - 2005 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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A case of osteoclast-like giant cell tumor of the pancreas. / Cho, Sang Hyung; Cheon, JaeHee; Lee, Sang Won; Park, Hong Suk; Kim, Seong Hoon; Park, Sang Jae; Lee, Woo Jin; Hong, Eun Kyung; Park, Joong Won.
In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 45, No. 6, 01.01.2005, p. 441-445.Research output: Contribution to journal › Article
TY - JOUR
T1 - A case of osteoclast-like giant cell tumor of the pancreas
AU - Cho, Sang Hyung
AU - Cheon, JaeHee
AU - Lee, Sang Won
AU - Park, Hong Suk
AU - Kim, Seong Hoon
AU - Park, Sang Jae
AU - Lee, Woo Jin
AU - Hong, Eun Kyung
AU - Park, Joong Won
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Osteoclast-like giant cell tumor of the pancreas is a very rare tumor. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may arise from epithelial precursors. This unusual tumor presents in the 6th or 7th decade with a nearly equal gender ratio. Pure forms of osteoclast-like giant cell tumor have a better prognosis because they have a predilection to local spread, are slower to metastasize and rarely metastasize to lymph nodes, but these forms are very rare. We present an osteoclast-like giant cell tumor arising in the body of the pancreas in a 71 year-old male patient. The tumor was composed of two major cell types: atypical mononuclear cells and abundant osteoclast-like multinucleated giant cells. Immunohistochemical studies showed that atypical cells were strongly reactive for vimentin and focally reactive for cytokeratin. In contrast, the giant cells were immunoreactive for CD68, but negative for cytokeratin. Three months later, the tumor size increased and liver metastasis was newly developed. He died at 11 months after the diagnosis.
AB - Osteoclast-like giant cell tumor of the pancreas is a very rare tumor. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may arise from epithelial precursors. This unusual tumor presents in the 6th or 7th decade with a nearly equal gender ratio. Pure forms of osteoclast-like giant cell tumor have a better prognosis because they have a predilection to local spread, are slower to metastasize and rarely metastasize to lymph nodes, but these forms are very rare. We present an osteoclast-like giant cell tumor arising in the body of the pancreas in a 71 year-old male patient. The tumor was composed of two major cell types: atypical mononuclear cells and abundant osteoclast-like multinucleated giant cells. Immunohistochemical studies showed that atypical cells were strongly reactive for vimentin and focally reactive for cytokeratin. In contrast, the giant cells were immunoreactive for CD68, but negative for cytokeratin. Three months later, the tumor size increased and liver metastasis was newly developed. He died at 11 months after the diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=33748741112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748741112&partnerID=8YFLogxK
M3 - Article
C2 - 15973080
AN - SCOPUS:33748741112
VL - 45
SP - 441
EP - 445
JO - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JF - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
SN - 1598-9992
IS - 6
ER -