A case of osteoclast-like giant cell tumor of the pancreas

Sang Hyung Cho, JaeHee Cheon, Sang Won Lee, Hong Suk Park, Seong Hoon Kim, Sang Jae Park, Woo Jin Lee, Eun Kyung Hong, Joong Won Park

Research output: Contribution to journalArticle

Abstract

Osteoclast-like giant cell tumor of the pancreas is a very rare tumor. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may arise from epithelial precursors. This unusual tumor presents in the 6th or 7th decade with a nearly equal gender ratio. Pure forms of osteoclast-like giant cell tumor have a better prognosis because they have a predilection to local spread, are slower to metastasize and rarely metastasize to lymph nodes, but these forms are very rare. We present an osteoclast-like giant cell tumor arising in the body of the pancreas in a 71 year-old male patient. The tumor was composed of two major cell types: atypical mononuclear cells and abundant osteoclast-like multinucleated giant cells. Immunohistochemical studies showed that atypical cells were strongly reactive for vimentin and focally reactive for cytokeratin. In contrast, the giant cells were immunoreactive for CD68, but negative for cytokeratin. Three months later, the tumor size increased and liver metastasis was newly developed. He died at 11 months after the diagnosis.

Original languageEnglish
Pages (from-to)441-445
Number of pages5
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume45
Issue number6
Publication statusPublished - 2005 Jan 1

Fingerprint

Giant Cell Tumors
Osteoclasts
Pancreas
Neoplasms
Giant Cells
Keratins
Vimentin
Tendons
Lymph Nodes
Neoplasm Metastasis
Bone and Bones
Liver

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cho, S. H., Cheon, J., Lee, S. W., Park, H. S., Kim, S. H., Park, S. J., ... Park, J. W. (2005). A case of osteoclast-like giant cell tumor of the pancreas. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 45(6), 441-445.
Cho, Sang Hyung ; Cheon, JaeHee ; Lee, Sang Won ; Park, Hong Suk ; Kim, Seong Hoon ; Park, Sang Jae ; Lee, Woo Jin ; Hong, Eun Kyung ; Park, Joong Won. / A case of osteoclast-like giant cell tumor of the pancreas. In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2005 ; Vol. 45, No. 6. pp. 441-445.
@article{fbf5fbe40cce4220a7535777ee1c7049,
title = "A case of osteoclast-like giant cell tumor of the pancreas",
abstract = "Osteoclast-like giant cell tumor of the pancreas is a very rare tumor. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may arise from epithelial precursors. This unusual tumor presents in the 6th or 7th decade with a nearly equal gender ratio. Pure forms of osteoclast-like giant cell tumor have a better prognosis because they have a predilection to local spread, are slower to metastasize and rarely metastasize to lymph nodes, but these forms are very rare. We present an osteoclast-like giant cell tumor arising in the body of the pancreas in a 71 year-old male patient. The tumor was composed of two major cell types: atypical mononuclear cells and abundant osteoclast-like multinucleated giant cells. Immunohistochemical studies showed that atypical cells were strongly reactive for vimentin and focally reactive for cytokeratin. In contrast, the giant cells were immunoreactive for CD68, but negative for cytokeratin. Three months later, the tumor size increased and liver metastasis was newly developed. He died at 11 months after the diagnosis.",
author = "Cho, {Sang Hyung} and JaeHee Cheon and Lee, {Sang Won} and Park, {Hong Suk} and Kim, {Seong Hoon} and Park, {Sang Jae} and Lee, {Woo Jin} and Hong, {Eun Kyung} and Park, {Joong Won}",
year = "2005",
month = "1",
day = "1",
language = "English",
volume = "45",
pages = "441--445",
journal = "The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi",
issn = "1598-9992",
publisher = "Korean Society of Gastroenterology",
number = "6",

}

Cho, SH, Cheon, J, Lee, SW, Park, HS, Kim, SH, Park, SJ, Lee, WJ, Hong, EK & Park, JW 2005, 'A case of osteoclast-like giant cell tumor of the pancreas', The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, vol. 45, no. 6, pp. 441-445.

A case of osteoclast-like giant cell tumor of the pancreas. / Cho, Sang Hyung; Cheon, JaeHee; Lee, Sang Won; Park, Hong Suk; Kim, Seong Hoon; Park, Sang Jae; Lee, Woo Jin; Hong, Eun Kyung; Park, Joong Won.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 45, No. 6, 01.01.2005, p. 441-445.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A case of osteoclast-like giant cell tumor of the pancreas

AU - Cho, Sang Hyung

AU - Cheon, JaeHee

AU - Lee, Sang Won

AU - Park, Hong Suk

AU - Kim, Seong Hoon

AU - Park, Sang Jae

AU - Lee, Woo Jin

AU - Hong, Eun Kyung

AU - Park, Joong Won

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Osteoclast-like giant cell tumor of the pancreas is a very rare tumor. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may arise from epithelial precursors. This unusual tumor presents in the 6th or 7th decade with a nearly equal gender ratio. Pure forms of osteoclast-like giant cell tumor have a better prognosis because they have a predilection to local spread, are slower to metastasize and rarely metastasize to lymph nodes, but these forms are very rare. We present an osteoclast-like giant cell tumor arising in the body of the pancreas in a 71 year-old male patient. The tumor was composed of two major cell types: atypical mononuclear cells and abundant osteoclast-like multinucleated giant cells. Immunohistochemical studies showed that atypical cells were strongly reactive for vimentin and focally reactive for cytokeratin. In contrast, the giant cells were immunoreactive for CD68, but negative for cytokeratin. Three months later, the tumor size increased and liver metastasis was newly developed. He died at 11 months after the diagnosis.

AB - Osteoclast-like giant cell tumor of the pancreas is a very rare tumor. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may arise from epithelial precursors. This unusual tumor presents in the 6th or 7th decade with a nearly equal gender ratio. Pure forms of osteoclast-like giant cell tumor have a better prognosis because they have a predilection to local spread, are slower to metastasize and rarely metastasize to lymph nodes, but these forms are very rare. We present an osteoclast-like giant cell tumor arising in the body of the pancreas in a 71 year-old male patient. The tumor was composed of two major cell types: atypical mononuclear cells and abundant osteoclast-like multinucleated giant cells. Immunohistochemical studies showed that atypical cells were strongly reactive for vimentin and focally reactive for cytokeratin. In contrast, the giant cells were immunoreactive for CD68, but negative for cytokeratin. Three months later, the tumor size increased and liver metastasis was newly developed. He died at 11 months after the diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=33748741112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748741112&partnerID=8YFLogxK

M3 - Article

C2 - 15973080

AN - SCOPUS:33748741112

VL - 45

SP - 441

EP - 445

JO - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

JF - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

SN - 1598-9992

IS - 6

ER -