A case of palmoplanar hyperhidrosis successfully treated with botulinum toxin B

Hyperhidrosis is an eccrine sweat gland disease that results from sympathetic hyperactivity, usually occurring on the axilla, palm, sole, or groin. It causes not only cosmetic problems, but also social stress in affected patients. Until now, several modalities have been used to treat focal hyperhidrosis, with variable clinical outcomes and complications, including skin irritation, neurological problems, and nonesthetic scar formation. Botulinum toxin type A has been used widely and successfully in the treatment of hyperhidrosis since 1981. Botulinum toxin type B has recently been introduced for off-label use after being approved by the Food and Drug Administration in 2000 for the treatment of cervical dystonia. However, there has been no report of Botulinum toxin type B treatment for palmoplanar hyperhidrosis in the Koreandermatologic literature. Herein, we report the first case of palmoplanar hyperhidrosis successfully treated with Botulinum Toxin B in Korea, along with a review of the literature.