A case of successful intrapleural chemotherapy with cisplatin plus cytarabine for intractable malignant pleural effusion

Yong Wha Moon, Sang Tae Choi, Byoung Chul Cho, Hye Jin Choi, Yong Tai Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

When conventional treatments of malignant pleural effusion, such as repeated thoracentesis, closed thoracotomy and pleurodesis by instilled sclerosing agents, are ineffective, there are few alternative therapies available. Our case involves a 47-year-old woman with uterine cervical carcinoma suffering from malignant pleural effusion. She presented with a chief complaint of severe dyspnea, and was classified as an Eastern Cooperative Oncology Group (ECOG) performance status of 4. Her underlying cervical carcinoma progressed despite various systemic chemotherapy regimens. In addition, pleural effusion persisted in spite of 4 weeks of drainage through the thoracotomy tube and talc pleurodesis. Under such circumstances, we attempted intrapleural chemotherapy with cisplatin plus cytarabine, which resulted in significant decrease of the pleural effusion. No serious systemic toxicities, including myelosuppression, were observed. As a result, the patient's dyspnea was relieved, and her ECOG performance status improved from 4 to 2. However, the thoracotomy tube was not removed due to subsequent iatrogenic pneumothorax. Pleural effusion did not recur for the 4 weeks leading up to her death.

Original languageEnglish
Pages (from-to)1035-1038
Number of pages4
JournalYonsei medical journal
Volume48
Issue number6
DOIs
Publication statusPublished - 2007 Dec 1

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Malignant Pleural Effusion
Cytarabine
Pleural Effusion
Thoracotomy
Cisplatin
Pleurodesis
Drug Therapy
Dyspnea
Sclerosing Solutions
Talc
Carcinoma
Pneumothorax
Complementary Therapies
Drainage
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Moon, Yong Wha ; Choi, Sang Tae ; Cho, Byoung Chul ; Choi, Hye Jin ; Kim, Yong Tai. / A case of successful intrapleural chemotherapy with cisplatin plus cytarabine for intractable malignant pleural effusion. In: Yonsei medical journal. 2007 ; Vol. 48, No. 6. pp. 1035-1038.
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A case of successful intrapleural chemotherapy with cisplatin plus cytarabine for intractable malignant pleural effusion. / Moon, Yong Wha; Choi, Sang Tae; Cho, Byoung Chul; Choi, Hye Jin; Kim, Yong Tai.

In: Yonsei medical journal, Vol. 48, No. 6, 01.12.2007, p. 1035-1038.

Research output: Contribution to journalArticle

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