A case of Wegener's granulomatosis with severe skin necrosis

Se Woong Oh, Soo Chan Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Wegener's granulomatosis is an uncommon condition characterized by necrotizing vasculitis of unknown cause. The classic clinical triad consists of necrotizing granulomatous inflammation of the respiratory tract, necrotizing glomerulonephiritis, and necrotizing vascultitis affecting predominantly small vessels. The skin manifestations are frequent, and the most common lesion is purpura distributed on the limbs and trunk. However, severe skin involvement is not common. A 20-year old female presented with purpuric macules on the whole body, which became necrotic. The lungs or kidneys were not affected. However, the histopathologic findings of the skin and nasal mucosa revealed the features of necrotizing vasculitis and granulomatous inflammation. Therefore, we diagnosed Wegener's granulomatosis, which showed unusually severe skin necrosis. She was treated with systemic corticosteroids and cyclophosphamide, but leukopenia, sepsis, and infective endocarditis continuously developed. She died of a cerebral hemorrhage due to overdose of coumadin, which had been used following a cardiac operation for infective endocarditis.

Original languageEnglish
Pages (from-to)892-895
Number of pages4
JournalKorean Journal of Dermatology
Volume44
Issue number7
Publication statusPublished - 2006 Jul 1

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Granulomatosis with Polyangiitis
Necrosis
Vasculitis
Endocarditis
Skin
Inflammation
Skin Manifestations
Purpura
Nasal Mucosa
Cerebral Hemorrhage
Leukopenia
Warfarin
Respiratory System
Cyclophosphamide
Sepsis
Adrenal Cortex Hormones
Extremities
Kidney
Lung

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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A case of Wegener's granulomatosis with severe skin necrosis. / Oh, Se Woong; Kim, Soo Chan.

In: Korean Journal of Dermatology, Vol. 44, No. 7, 01.07.2006, p. 892-895.

Research output: Contribution to journalArticle

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