A cationic zinc porphyrin as a chiroptical probe for Z-DNA

Milan Balaz, Massimo De Napoli, Andrea E. Holmes, Angela Mammana, Koji Nakanishi, Nina Berova, Roberto Purrello

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108 Citations (Scopus)


Z for zinc and Z-DNA: As a result of different binding modes, a cationic zinc porphyrin discriminates between B and Z conformations of DNA and holds promise as a probe for Z-DNA. A very intense induced circular dichroism (ICD) effect with a bisignate spectrum is observed upon interaction of the porphyrin with Z-DNA (see graphic; porphyrin red, Z-DNA green), whereas only a weak ICD spectrum results upon its interaction with B-DNA (Figure Presented).

Original languageEnglish
Pages (from-to)4006-4009
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number26
Publication statusPublished - 2005 Jun 27

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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    Balaz, M., De Napoli, M., Holmes, A. E., Mammana, A., Nakanishi, K., Berova, N., & Purrello, R. (2005). A cationic zinc porphyrin as a chiroptical probe for Z-DNA. Angewandte Chemie - International Edition, 44(26), 4006-4009. https://doi.org/10.1002/anie.200501149