A cationic zinc porphyrin as a chiroptical probe for Z-DNA

Milan Balaz, Massimo De Napoli, Andrea E. Holmes, Angela Mammana, Koji Nakanishi, Nina Berova, Roberto Purrello

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Z for zinc and Z-DNA: As a result of different binding modes, a cationic zinc porphyrin discriminates between B and Z conformations of DNA and holds promise as a probe for Z-DNA. A very intense induced circular dichroism (ICD) effect with a bisignate spectrum is observed upon interaction of the porphyrin with Z-DNA (see graphic; porphyrin red, Z-DNA green), whereas only a weak ICD spectrum results upon its interaction with B-DNA (Figure Presented).

Original languageEnglish
Pages (from-to)4006-4009
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number26
DOIs
Publication statusPublished - 2005 Jun 27

Fingerprint

Z-Form DNA
Porphyrins
DNA
Zinc
Dichroism
B-Form DNA
Conformations
zinc hematoporphyrin

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Balaz, M., De Napoli, M., Holmes, A. E., Mammana, A., Nakanishi, K., Berova, N., & Purrello, R. (2005). A cationic zinc porphyrin as a chiroptical probe for Z-DNA. Angewandte Chemie - International Edition, 44(26), 4006-4009. https://doi.org/10.1002/anie.200501149
Balaz, Milan ; De Napoli, Massimo ; Holmes, Andrea E. ; Mammana, Angela ; Nakanishi, Koji ; Berova, Nina ; Purrello, Roberto. / A cationic zinc porphyrin as a chiroptical probe for Z-DNA. In: Angewandte Chemie - International Edition. 2005 ; Vol. 44, No. 26. pp. 4006-4009.
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Balaz, M, De Napoli, M, Holmes, AE, Mammana, A, Nakanishi, K, Berova, N & Purrello, R 2005, 'A cationic zinc porphyrin as a chiroptical probe for Z-DNA', Angewandte Chemie - International Edition, vol. 44, no. 26, pp. 4006-4009. https://doi.org/10.1002/anie.200501149

A cationic zinc porphyrin as a chiroptical probe for Z-DNA. / Balaz, Milan; De Napoli, Massimo; Holmes, Andrea E.; Mammana, Angela; Nakanishi, Koji; Berova, Nina; Purrello, Roberto.

In: Angewandte Chemie - International Edition, Vol. 44, No. 26, 27.06.2005, p. 4006-4009.

Research output: Contribution to journalArticle

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AU - Berova, Nina

AU - Purrello, Roberto

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AB - Z for zinc and Z-DNA: As a result of different binding modes, a cationic zinc porphyrin discriminates between B and Z conformations of DNA and holds promise as a probe for Z-DNA. A very intense induced circular dichroism (ICD) effect with a bisignate spectrum is observed upon interaction of the porphyrin with Z-DNA (see graphic; porphyrin red, Z-DNA green), whereas only a weak ICD spectrum results upon its interaction with B-DNA (Figure Presented).

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Balaz M, De Napoli M, Holmes AE, Mammana A, Nakanishi K, Berova N et al. A cationic zinc porphyrin as a chiroptical probe for Z-DNA. Angewandte Chemie - International Edition. 2005 Jun 27;44(26):4006-4009. https://doi.org/10.1002/anie.200501149