A clinical study on the effect of a facial cleanser consisting of 1% triclosan and 0.5% Ku Shen on acne vulgaris

Ho Lee Nam Ho Lee, Ho Choi Eung Ho Choi, Ku Ahn Sung Ku Ahn, Hun Lee Seung Hun Lee

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Abstract

Background: Acne is a relatively common disorder, especially in the adolescent. The condition is characterized by comedones, papules and pustules. Acne patients frequently wash their face. Cleansing with an effective agent is therapeutic and preventive for patients suffering from acne vulgaris. Objective: The study was designed to compare the efficacy and safety of a facial cleanser consisting of 1% triclosan and 0.5% Ku Shen and a in the treatment of facial acne vulgaris. Methods: The study was carried out on two groups of people: a treatment and a control group. Efficacy and safety were assessed at baseline and at weeks 1, 2, 3, 4, 6, 8, 10 and 12. Efficacy was determined by investigating counts of non-inflammatory open and closed comedones, and inflammatory papules and pustules. Global improvement was also assessed. Results: At week 12, the mean counts in the different lesions were as follows; 11.2 versus 17.2 for total lesions (p<0.05); 9.4 versus 11.3 for non-inflammatory lesions (p<0.05); 1.8 versus 5.9 for inflammatory lesions (p<0.05) in the treatment and control groups, respectively. A Statistically significant difference was observed in patients overall self-assessment (p<0.05). The Group applying the facial cleanser with 1% triclosan and 0.5% Ku Shen felt significantly better than the one applying the control facial cleanser. Some patients developed mild and transient local side effects. Conclusion: Cleansing three times a day with a facial cleanser consisting of 1% triclosan and 0.5% Ku Shen was found to be effective and safe for patients suffering from acne vulgaris.

Original languageEnglish
Pages (from-to)871-876
Number of pages6
JournalKorean Journal of Dermatology
Volume36
Issue number5
Publication statusPublished - 1998 Dec 1

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All Science Journal Classification (ASJC) codes

  • Dermatology

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