A collagen-AS/ϵPLL bilayered artificial substitute regulates anti-inflammation and infection for initial inflamed wound healing

Gyeung Mi Seon, Mi Hee Lee, Min Ah Koo, Seung Hee Hong, Ye Jin Park, Ha Kyeong Jeong, Jong Chul Park

Research output: Contribution to journalArticlepeer-review

Abstract

Despite the development of advanced tissue engineering substitutes, inflammation is still a significant problem that can arise from inflamed burn injuries, chronic wounds, or microbial diseases. Although topical wound dressing accelerates healing by minimizing or preventing the consequences of skin inflammation, there remains a need for the development of a novel substitute scaffold that can effectively eliminate immoderate inflammation and infection in the initial phase of the healing meachanism. In this study, an artificial skin substitute scaffold fabricated with asiaticoside (AS) and epsilon-poly-l-lysine (ϵPLL) was prepared. Upon the release of these bioactive compounds, they accelerate wound healing and inhibit any bacterial infection at the wound site. We determined whether AS and ϵPLL exhibit anti-inflammatory and bactericidal effects through different mechanisms. Collectively, the collagen-AS/ϵPLL artificial skin substitute could be a significant therapeutic agent for scar-less rapid wound healing (without infection and inflammation) of initially-inflamed full-thickness wounds. This journal is

Original languageEnglish
Pages (from-to)6865-6878
Number of pages14
JournalBiomaterials Science
Volume9
Issue number20
DOIs
Publication statusPublished - 2021 Oct 21

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation (NRF) grant funded by the Korean government (MSIT) (No. 2017M3A9B3063638, 2019R1A2C2005256).

Publisher Copyright:
© The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Materials Science(all)

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