A comparison of clinical features and mortality among methicillin-resistant and methicillin-sensitive strains of Staphylococcus aureus endocarditis

Hee Jung Yoon, JunYong Choi, Chang Oh Kim, June Myung Kim, Young Goo Song

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Our objective was to assess the clinical factors that would reliably distinguish methicillin-resistant S. aureus (MRSA) from methicillin-susceptible S. aureus (MSSA) endocarditis. A retrospective cohort study of clinical features and mortality in patients with MRSA and MSSA endocarditis between March 1986 and March 2004 was performed in a 750-bed, tertiary care teaching hospital. A total of 32 patients (10 MRSA [31.3%] vs 22 MSSA [68.7%]) were evaluated. Their mean age and sex ratio (male/female) were as follows: 30.8±16.0 vs 24.4±19.6 years old and 6/4 vs 13/9, for MRSA and MSSA infective endocarditis (IE), respectively. Univariate and multivariate analyses revealed that persistent bacteremia was significantly more prevalent in MRSA IE (OR, 10.0 [1.480-67.552]; p, 0.018). There was a higher mortality trend for MRSA IE (50.0%) than for MSSA IE (9.1%) (p=0.019). However, persistent bacteremia was not associated with higher mortality (p>0.05). These results indicate that if persistent bacteremia is documented, the likelihood of MRSA endocarditis should be viewed as high, and the patient's antistaphylococcal therapy should be prolonged and/or changed to a more "potent" regimen.

Original languageEnglish
Pages (from-to)496-502
Number of pages7
JournalYonsei medical journal
Volume46
Issue number4
DOIs
Publication statusPublished - 2005 Aug 31

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Methicillin Resistance
Methicillin
Methicillin-Resistant Staphylococcus aureus
Endocarditis
Staphylococcus aureus
Mortality
Bacteremia
Sex Ratio
Tertiary Healthcare
Teaching Hospitals
Cohort Studies
Multivariate Analysis
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Our objective was to assess the clinical factors that would reliably distinguish methicillin-resistant S. aureus (MRSA) from methicillin-susceptible S. aureus (MSSA) endocarditis. A retrospective cohort study of clinical features and mortality in patients with MRSA and MSSA endocarditis between March 1986 and March 2004 was performed in a 750-bed, tertiary care teaching hospital. A total of 32 patients (10 MRSA [31.3{\%}] vs 22 MSSA [68.7{\%}]) were evaluated. Their mean age and sex ratio (male/female) were as follows: 30.8±16.0 vs 24.4±19.6 years old and 6/4 vs 13/9, for MRSA and MSSA infective endocarditis (IE), respectively. Univariate and multivariate analyses revealed that persistent bacteremia was significantly more prevalent in MRSA IE (OR, 10.0 [1.480-67.552]; p, 0.018). There was a higher mortality trend for MRSA IE (50.0{\%}) than for MSSA IE (9.1{\%}) (p=0.019). However, persistent bacteremia was not associated with higher mortality (p>0.05). These results indicate that if persistent bacteremia is documented, the likelihood of MRSA endocarditis should be viewed as high, and the patient's antistaphylococcal therapy should be prolonged and/or changed to a more {"}potent{"} regimen.",
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A comparison of clinical features and mortality among methicillin-resistant and methicillin-sensitive strains of Staphylococcus aureus endocarditis. / Yoon, Hee Jung; Choi, JunYong; Kim, Chang Oh; Kim, June Myung; Song, Young Goo.

In: Yonsei medical journal, Vol. 46, No. 4, 31.08.2005, p. 496-502.

Research output: Contribution to journalArticle

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