A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011-2012 Influenza Season in Korea

A Multi-Center Study

Seong Heon Wie, Byung Hak So, Joon Young Song, Hee Jin Cheong, Yu Bin Seo, Sung Hyuk Choi, Ji Yun Noh, Ji Hyeon Baek, Jin Soo Lee, Hyo Youl Kim, YoungKeun Kim, Won Suk Choi, Jacob Lee, Hye Won Jeong, Woo Joo Kim

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background:During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B.Methodology/Principal Findings:We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2%) had influenza A (H3N2), and 194 (22.8%) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05).Conclusions:The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza.

Original languageEnglish
Article numbere62685
JournalPloS one
Volume8
Issue number5
DOIs
Publication statusPublished - 2013 May 3

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Korea
Medical problems
influenza
Human Influenza
Korean Peninsula
Viruses
Emergency rooms
Pulmonary diseases
hypertension
diabetes
Hypertension
cardiovascular diseases
Length of Stay
Hospitalization
neuromuscular disorders
viruses
Neuromuscular Diseases
Republic of Korea
leukopenia
thrombocytopenia

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Wie, Seong Heon ; So, Byung Hak ; Song, Joon Young ; Cheong, Hee Jin ; Seo, Yu Bin ; Choi, Sung Hyuk ; Noh, Ji Yun ; Baek, Ji Hyeon ; Lee, Jin Soo ; Kim, Hyo Youl ; Kim, YoungKeun ; Choi, Won Suk ; Lee, Jacob ; Jeong, Hye Won ; Kim, Woo Joo. / A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011-2012 Influenza Season in Korea : A Multi-Center Study. In: PloS one. 2013 ; Vol. 8, No. 5.
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title = "A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011-2012 Influenza Season in Korea: A Multi-Center Study",
abstract = "Background:During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B.Methodology/Principal Findings:We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2{\%}) had influenza A (H3N2), and 194 (22.8{\%}) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05).Conclusions:The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza.",
author = "Wie, {Seong Heon} and So, {Byung Hak} and Song, {Joon Young} and Cheong, {Hee Jin} and Seo, {Yu Bin} and Choi, {Sung Hyuk} and Noh, {Ji Yun} and Baek, {Ji Hyeon} and Lee, {Jin Soo} and Kim, {Hyo Youl} and YoungKeun Kim and Choi, {Won Suk} and Jacob Lee and Jeong, {Hye Won} and Kim, {Woo Joo}",
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A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011-2012 Influenza Season in Korea : A Multi-Center Study. / Wie, Seong Heon; So, Byung Hak; Song, Joon Young; Cheong, Hee Jin; Seo, Yu Bin; Choi, Sung Hyuk; Noh, Ji Yun; Baek, Ji Hyeon; Lee, Jin Soo; Kim, Hyo Youl; Kim, YoungKeun; Choi, Won Suk; Lee, Jacob; Jeong, Hye Won; Kim, Woo Joo.

In: PloS one, Vol. 8, No. 5, e62685, 03.05.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011-2012 Influenza Season in Korea

T2 - A Multi-Center Study

AU - Wie, Seong Heon

AU - So, Byung Hak

AU - Song, Joon Young

AU - Cheong, Hee Jin

AU - Seo, Yu Bin

AU - Choi, Sung Hyuk

AU - Noh, Ji Yun

AU - Baek, Ji Hyeon

AU - Lee, Jin Soo

AU - Kim, Hyo Youl

AU - Kim, YoungKeun

AU - Choi, Won Suk

AU - Lee, Jacob

AU - Jeong, Hye Won

AU - Kim, Woo Joo

PY - 2013/5/3

Y1 - 2013/5/3

N2 - Background:During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B.Methodology/Principal Findings:We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2%) had influenza A (H3N2), and 194 (22.8%) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05).Conclusions:The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza.

AB - Background:During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B.Methodology/Principal Findings:We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2%) had influenza A (H3N2), and 194 (22.8%) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05).Conclusions:The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza.

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M3 - Article

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