A comprehensive analysis of clinical trials in the COVID-19 pandemic era

Jinhee Lee, Han Wul Shin, Jun Young Lee, Jae Seok Kim, Jae Won Yang, Keum Hwa Lee, Andreas Kronbichler, Jae Il Shin

Research output: Contribution to journalArticle

Abstract

Background and objective: Despite medical advances, we are facing the unprecedented disaster of the coronavirus disease 2019 (COVID-19) pandemic without available treatments and effective vaccines. As the COVID-19 pandemic has approached its culmination, desperate efforts have been made to seek proper treatments and response strategies, and the number of clinical trials has been rapidly increasing. In this time of the pandemic, it is believed that learning lessons from it would be meaningful in preparing for future pandemics. Thus, this study aims at providing a comprehensive landscape of COVID-19 related clinical trials based on the ClinicalTrials.gov database. Materials and methods: Up to 30 March 2020, we identified a total of 147 eligible clinical trials and reviewed the overview of the studies. Results: Until then, the most clinical trials were set up in China. Treatment approaches are the most frequent purpose of the registered studies. Chloroquine, interferon, and antiviral agents such as remdesivir, lopinavir, and ritonavir are agents under investigation in these trials. Conclusions: In this study, we introduced the promising therapeutic options that many researchers and clinicians are interested in, and to address the hidden issues behind clinical trials in this COVID-19 pandemic.

Original languageEnglish
Article number315
JournalMedicina
Volume56
Issue number6
DOIs
Publication statusPublished - 2020 Jun

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Lee, J., Shin, H. W., Lee, J. Y., Kim, J. S., Yang, J. W., Lee, K. H., Kronbichler, A., & Shin, J. I. (2020). A comprehensive analysis of clinical trials in the COVID-19 pandemic era. Medicina, 56(6), [315]. https://doi.org/10.3390/medicina56060315