A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma

Kang Su Cho, Young Deuk Choi, Se Joong Kim, Chun Il Kim, Byung Ha Chung, Do Hwan Seong, Dong Hyeon Lee, Jin Seon Cho, In Rae Cho, Sung Joon Hong

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Abstract

Purpose: To develop a reliable prognostic model for patients with metastatic renal cell carcinoma (RCC) based on features readily available in common clinical settings. Patients and Methods: A total of 197 patients with RCC who underwent nephrectomy and immunotherapy from 1995 to 2004 were retrospectively reviewed. Their mean age was 55.1 ± 11.8 yrs (24-83 yrs) and mean survival time from metastasis was 22.6 ± 20.2 mos (3-120 mos). The impact of 24 clinicopathological features on disease specific survival was investigated. Results: On univariate analysis, constitutional symptoms, sarcomatoid differentiation, tumor necrosis, multiple primary lesions, liver metastasis, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), thrombocytosis, alkaline pbosphatase, hematocrit, T stage, N stage, and nuclear grade had significant influence on survival (p < 0.05). Multivariate analysis revealed the following features associated with survival: sarcomatoid differentiation [hazard ratio (HR)=2.99, p<0.001], liver metastasis (HR = 2.09, p = 0.002), ECOG-PS (HR = 1.95, p = 0.005), N stage (HR = 1.94, p = 0.002), and number of metastatic sites (HR = 1.76, p = 0.003). An individual prognostic score was defined as the sum of the weight of these features. According to prognostic scores, patients could be subdivided into 3 groups: low risk (score 0), intermediate risk (score 1 or 2), and high risk (score ≥ 3). Conclusion: A comprehensive prognostic stratification model was developed to predict survival and stratify patients for prospective clinical trials.

Original languageEnglish
Pages (from-to)451-458
Number of pages8
JournalYonsei medical journal
Volume49
Issue number3
DOIs
Publication statusPublished - 2008 Jun

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Cho, K. S., Choi, Y. D., Kim, S. J., Kim, C. I., Chung, B. H., Seong, D. H., Lee, D. H., Cho, J. S., Cho, I. R., & Hong, S. J. (2008). A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma. Yonsei medical journal, 49(3), 451-458. https://doi.org/10.3349/ymj.2008.49.3.451