A concise synthesis and in vitro cytotoxicity of new labdane diterpenes

Mankil Jung, Imju Ko, Seokjoon Lee, Sun Ju Choi, Byoung Hee Youn, Soo Kie Kim

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A new series of labdane-related diterpenes have been synthesized from (- )-sclareoi and assayed in vitro cytotoxicity against mouse and human cancer cells. A key intermediate, homodrimane and furanolabdane derivatives show good in vitro cytotoxicity comparable to those of mitomycin C and adriamycin.

Original languageEnglish
Pages (from-to)3295-3298
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number23
DOIs
Publication statusPublished - 1998 Dec 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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