A concise synthesis and in vitro cytotoxicity of new labdane diterpenes

Mankil Jung, Imju Ko, Seokjoon Lee, Sun Ju Choi, Byoung Hee Youn, Soo Kie Kim

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A new series of labdane-related diterpenes have been synthesized from (- )-sclareoi and assayed in vitro cytotoxicity against mouse and human cancer cells. A key intermediate, homodrimane and furanolabdane derivatives show good in vitro cytotoxicity comparable to those of mitomycin C and adriamycin.

Original languageEnglish
Pages (from-to)3295-3298
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number23
DOIs
Publication statusPublished - 1998 Dec 1

Fingerprint

Diterpenes
Cytotoxicity
Mitomycin
Doxorubicin
Cells
Derivatives
Neoplasms
In Vitro Techniques
labdane

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Jung, Mankil ; Ko, Imju ; Lee, Seokjoon ; Choi, Sun Ju ; Youn, Byoung Hee ; Kim, Soo Kie. / A concise synthesis and in vitro cytotoxicity of new labdane diterpenes. In: Bioorganic and Medicinal Chemistry Letters. 1998 ; Vol. 8, No. 23. pp. 3295-3298.
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A concise synthesis and in vitro cytotoxicity of new labdane diterpenes. / Jung, Mankil; Ko, Imju; Lee, Seokjoon; Choi, Sun Ju; Youn, Byoung Hee; Kim, Soo Kie.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 23, 01.12.1998, p. 3295-3298.

Research output: Contribution to journalArticle

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