A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F

Younghwa Na, JeongHeon Cha, Ho Geun Yoon, Youngjoo Kwon

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regioisomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis.

Original languageEnglish
Pages (from-to)607-609
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume57
Issue number6
DOIs
Publication statusPublished - 2009 Jun 1

Fingerprint

Isomers
Glycyrrhiza
Type I DNA Topoisomerase
Endothelial cells
Tumor Cell Line
Tumors
Endothelial Cells
Cells
Apoptosis
Research
licochalcone E
licochalcone F

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Chemistry(all)

Cite this

Na, Younghwa ; Cha, JeongHeon ; Yoon, Ho Geun ; Kwon, Youngjoo. / A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F. In: Chemical and Pharmaceutical Bulletin. 2009 ; Vol. 57, No. 6. pp. 607-609.
@article{a0c68742cbe441ce971dd274efab61d6,
title = "A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F",
abstract = "Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regioisomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis.",
author = "Younghwa Na and JeongHeon Cha and Yoon, {Ho Geun} and Youngjoo Kwon",
year = "2009",
month = "6",
day = "1",
doi = "10.1248/cpb.57.607",
language = "English",
volume = "57",
pages = "607--609",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "Pharmaceutical Society of Japan",
number = "6",

}

A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F. / Na, Younghwa; Cha, JeongHeon; Yoon, Ho Geun; Kwon, Youngjoo.

In: Chemical and Pharmaceutical Bulletin, Vol. 57, No. 6, 01.06.2009, p. 607-609.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F

AU - Na, Younghwa

AU - Cha, JeongHeon

AU - Yoon, Ho Geun

AU - Kwon, Youngjoo

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regioisomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis.

AB - Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regioisomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis.

UR - http://www.scopus.com/inward/record.url?scp=66949143704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66949143704&partnerID=8YFLogxK

U2 - 10.1248/cpb.57.607

DO - 10.1248/cpb.57.607

M3 - Article

VL - 57

SP - 607

EP - 609

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 6

ER -