A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F

Younghwa Na, Jeong Heon Cha, Ho Geun Yoon, Youngjoo Kwon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regioisomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis.

Original languageEnglish
Pages (from-to)607-609
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume57
Issue number6
DOIs
Publication statusPublished - 2009 Jun

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Fingerprint Dive into the research topics of 'A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F'. Together they form a unique fingerprint.

  • Cite this