A convenient, one-pot procedure for the preparation of acyl and sulfonyl fluorides using Cl3CCN, Ph3P, and TBAF(t -BuOH) 4

Joong Gon Kim, Doo Ok Jang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Various carboxylic acids were converted into acyl fluorides in excellent yields by treatment with trichloroacetonitrile, triphenylphosphine, and TBAF(t-BuOH)4 at room temperature. The reaction was applicable to the preparation of acid-sensitive amino acid fluorides without deprotection or rearrangement

Original languageEnglish
Article numberU08710ST
Pages (from-to)3049-3052
Number of pages4
JournalSynlett
Issue number20
DOIs
Publication statusPublished - 2010 Nov 22

Fingerprint

Fluorides
Carboxylic Acids
Amino Acids
Acids
Temperature
sulfuryl fluoride
trichloroacetonitrile
triphenylphosphine

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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abstract = "Various carboxylic acids were converted into acyl fluorides in excellent yields by treatment with trichloroacetonitrile, triphenylphosphine, and TBAF(t-BuOH)4 at room temperature. The reaction was applicable to the preparation of acid-sensitive amino acid fluorides without deprotection or rearrangement",
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A convenient, one-pot procedure for the preparation of acyl and sulfonyl fluorides using Cl3CCN, Ph3P, and TBAF(t -BuOH) 4. / Kim, Joong Gon; Jang, Doo Ok.

In: Synlett, No. 20, U08710ST, 22.11.2010, p. 3049-3052.

Research output: Contribution to journalArticle

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