A convenient, one-pot procedure for the preparation of acyl and sulfonyl fluorides using Cl3CCN, Ph3P, and TBAF(t -BuOH) 4

Joong Gon Kim, Doo Ok Jang

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Various carboxylic acids were converted into acyl fluorides in excellent yields by treatment with trichloroacetonitrile, triphenylphosphine, and TBAF(t-BuOH)4 at room temperature. The reaction was applicable to the preparation of acid-sensitive amino acid fluorides without deprotection or rearrangement

Original languageEnglish
Article numberU08710ST
Pages (from-to)3049-3052
Number of pages4
Issue number20
Publication statusPublished - 2010 Nov 22


All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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