A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier

Yong Beom Lim, Oh Joon Kwon, Eunji Lee, Pyung Hwan Kim, Chae Ok Yun, Myongsoo Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have synthesized a peptide-based supramolecular building block consisting of a cyclic Arg-Gly-Asp (cRGD) peptide segment and a β-sheet-forming peptide segment. The block peptide was shown to self-assemble into a cRGD-coated nanoribbon structure, as revealed by circular dichroism (CD), dynamic light scattering (DLS), and transmission electron microscopy (TEM) studies. We have shown that this cRGD-coated nanoribbon can encapsulate hydrophobic guest molecules and deliver them into cells. Colocalization of the nanoribbon with LysoTracker and the selective intracellular delivery results suggests that the cRGD-coated nanoribbon is likely to be internalized into the cells through integrin receptors.

Original languageEnglish
Pages (from-to)1944-1948
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number11
DOIs
Publication statusPublished - 2008 May 26

Fingerprint

Carbon Nanotubes
peptides
Peptides
light transmission
Dynamic light scattering
Light transmission
Circular Dichroism
cells
Transmission Electron Microscopy
Integrins
dichroism
delivery
light scattering
Transmission electron microscopy
transmission electron microscopy
Molecules
cyclic arginine-glycine-aspartic acid peptide
arginyl-glycyl-aspartic acid
molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Lim, Yong Beom ; Kwon, Oh Joon ; Lee, Eunji ; Kim, Pyung Hwan ; Yun, Chae Ok ; Lee, Myongsoo. / A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier. In: Organic and Biomolecular Chemistry. 2008 ; Vol. 6, No. 11. pp. 1944-1948.
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A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier. / Lim, Yong Beom; Kwon, Oh Joon; Lee, Eunji; Kim, Pyung Hwan; Yun, Chae Ok; Lee, Myongsoo.

In: Organic and Biomolecular Chemistry, Vol. 6, No. 11, 26.05.2008, p. 1944-1948.

Research output: Contribution to journalArticle

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T1 - A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier

AU - Lim, Yong Beom

AU - Kwon, Oh Joon

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AU - Kim, Pyung Hwan

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AU - Lee, Myongsoo

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AB - We have synthesized a peptide-based supramolecular building block consisting of a cyclic Arg-Gly-Asp (cRGD) peptide segment and a β-sheet-forming peptide segment. The block peptide was shown to self-assemble into a cRGD-coated nanoribbon structure, as revealed by circular dichroism (CD), dynamic light scattering (DLS), and transmission electron microscopy (TEM) studies. We have shown that this cRGD-coated nanoribbon can encapsulate hydrophobic guest molecules and deliver them into cells. Colocalization of the nanoribbon with LysoTracker and the selective intracellular delivery results suggests that the cRGD-coated nanoribbon is likely to be internalized into the cells through integrin receptors.

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