A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier

Yong Beom Lim, Oh Joon Kwon, Eunji Lee, Pyung Hwan Kim, Chae Ok Yun, Myongsoo Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We have synthesized a peptide-based supramolecular building block consisting of a cyclic Arg-Gly-Asp (cRGD) peptide segment and a β-sheet-forming peptide segment. The block peptide was shown to self-assemble into a cRGD-coated nanoribbon structure, as revealed by circular dichroism (CD), dynamic light scattering (DLS), and transmission electron microscopy (TEM) studies. We have shown that this cRGD-coated nanoribbon can encapsulate hydrophobic guest molecules and deliver them into cells. Colocalization of the nanoribbon with LysoTracker and the selective intracellular delivery results suggests that the cRGD-coated nanoribbon is likely to be internalized into the cells through integrin receptors.

Original languageEnglish
Pages (from-to)1944-1948
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number11
DOIs
Publication statusPublished - 2008 May 26

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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