A deep belief network and Dempster-Shafer-based multiclassifier for the pathology stage of prostate cancer

Jae Kwon Kim, Mun Joo Choi, Jong Sik Lee, Jun Hyuk Hong, Choung Soo Kim, Seong Il Seo, Chang Wook Jeong, Seok Soo Byun, Kyo Chul Koo, Byung Ha Chung, Yong Hyun Park, Ji Youl Lee, In Young Choi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Object. Pathologic prediction of prostate cancer can be made by predicting the patient's prostate metastasis prior to surgery based on biopsy information. Because biopsy variables associated with pathology have uncertainty regarding individual patient differences, a method for classification according to these variables is needed. Method. We propose a deep belief network and Dempster-Shafer- (DBN-DS-) based multiclassifier for the pathologic prediction of prostate cancer. The DBN-DS learns prostate-specific antigen (PSA), Gleason score, and clinical T stage variable information using three DBNs. Uncertainty regarding the predicted output was removed from the DBN and combined with information from DS to make a correct decision. Result. The new method was validated on pathology data from 6342 patients with prostate cancer. The pathology stages consisted of organ-confined disease (OCD; 3892 patients) and non-organ-confined disease (NOCD; 2453 patients). The results showed that the accuracy of the proposed DBN-DS was 81.27%, which is higher than the 64.14% of the Partin table. Conclusion. The proposed DBN-DS is more effective than other methods in predicting pathology stage. The performance is high because of the linear combination using the results of pathology-related features. The proposed method may be effective in decision support for prostate cancer treatment.

Original languageEnglish
Article number4651582
JournalJournal of Healthcare Engineering
Volume2018
DOIs
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surgery
  • Biomedical Engineering
  • Health Informatics

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    Kim, J. K., Choi, M. J., Lee, J. S., Hong, J. H., Kim, C. S., Seo, S. I., Jeong, C. W., Byun, S. S., Koo, K. C., Chung, B. H., Park, Y. H., Lee, J. Y., & Choi, I. Y. (2018). A deep belief network and Dempster-Shafer-based multiclassifier for the pathology stage of prostate cancer. Journal of Healthcare Engineering, 2018, [4651582]. https://doi.org/10.1155/2018/4651582