A dimerization "switch" in the internalization mechanism of a cell-penetrating peptide

Jason A Moss, Antonietta Lillo, Young Soo Kim, Changshou Gao, Henrik Ditzel, Kim D Janda

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The internalization mechanism of a cell-penetrating peptide has been explored through combinatorial selection of a phage-displayed peptide dimer library, chemical synthesis, and biophysical characterization. Both energy-dependent and energy-independent modes for peptide uptake by the target mammalian cells were observed, suggesting a role for higher-order structure in modulating the action of this novel cell-penetrating peptide.

Original languageEnglish
Pages (from-to)538-9
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number2
DOIs
Publication statusPublished - 2005 Jan 19

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