A facile method for preparation of polycaprolactone/tricalcium phosphate fibrous matrix with a gradient mineral content

Dong Hyun Paik; Ki Young Jeong; Seung Kwan Moon; Myeong Jin Oh; Tae Kyung Ryu; Sung Eun Kim; Jung Hyun Kim; Jong Hoon Park; Sung Wook Choi

doi:10.1016/j.colsurfa.2013.03.063

A facile method for preparation of polycaprolactone/tricalcium phosphate fibrous matrix with a gradient mineral content

Dong Hyun Paik, Ki Young Jeong, Seung Kwan Moon, Myeong Jin Oh, Tae Kyung Ryu, Sung Eun Kim, Jung Hyun Kim, Jong Hoon Park, Sung Wook Choi

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We have demonstrated a facile method for the fabrication of biomimetic poly(caprolactone) (PCL) fibrous matrix with gradation in tricalcium phosphate (TCP) content. PCL solution in chloroform containing TCP powders was centrifuged for inducing gradient content in TCP. The PCL solution with centrifuged TCP was electrospun into the collector, resulting in the TCP-gradient PCL fibrous matrix with a high content of TCP at the bottom and nearly zero content at the top of the matrix. Cell culture on the fibrous matrices with low and high contents confirmed that osteoblast (MC3T3-E1) favored the fibrous matrix with a high TCP content in terms of proliferation and osteogenic differentiation. The TCP-gradient PCL fibrous matrix can potentially be employed for the biomedical application to the bone and bone-to-tendon regeneration.

Original language	English
Pages (from-to)	134-141
Number of pages	8
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	429
DOIs	https://doi.org/10.1016/j.colsurfa.2013.03.063
Publication status	Published - 2013 Jul

Bibliographical note

Funding Information:
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011-0023064 ), a grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( A110416 ), a grant from the “GRRC” Project of Gyeonggi Provincial Government, Korea , and the Research Fund, 2012 of The Catholic University of Korea .

All Science Journal Classification (ASJC) codes

Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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title = "A facile method for preparation of polycaprolactone/tricalcium phosphate fibrous matrix with a gradient mineral content",

abstract = "We have demonstrated a facile method for the fabrication of biomimetic poly(caprolactone) (PCL) fibrous matrix with gradation in tricalcium phosphate (TCP) content. PCL solution in chloroform containing TCP powders was centrifuged for inducing gradient content in TCP. The PCL solution with centrifuged TCP was electrospun into the collector, resulting in the TCP-gradient PCL fibrous matrix with a high content of TCP at the bottom and nearly zero content at the top of the matrix. Cell culture on the fibrous matrices with low and high contents confirmed that osteoblast (MC3T3-E1) favored the fibrous matrix with a high TCP content in terms of proliferation and osteogenic differentiation. The TCP-gradient PCL fibrous matrix can potentially be employed for the biomedical application to the bone and bone-to-tendon regeneration.",

author = "Paik, {Dong Hyun} and Jeong, {Ki Young} and Moon, {Seung Kwan} and Oh, {Myeong Jin} and Ryu, {Tae Kyung} and Kim, {Sung Eun} and Kim, {Jung Hyun} and Park, {Jong Hoon} and Choi, {Sung Wook}",

note = "Funding Information: This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011-0023064 ), a grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( A110416 ), a grant from the “GRRC” Project of Gyeonggi Provincial Government, Korea , and the Research Fund, 2012 of The Catholic University of Korea .",

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AU - Paik, Dong Hyun

AU - Jeong, Ki Young

AU - Moon, Seung Kwan

AU - Oh, Myeong Jin

AU - Ryu, Tae Kyung

AU - Kim, Sung Eun

AU - Kim, Jung Hyun

AU - Park, Jong Hoon

AU - Choi, Sung Wook

N1 - Funding Information: This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011-0023064 ), a grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( A110416 ), a grant from the “GRRC” Project of Gyeonggi Provincial Government, Korea , and the Research Fund, 2012 of The Catholic University of Korea .

PY - 2013/7

Y1 - 2013/7

N2 - We have demonstrated a facile method for the fabrication of biomimetic poly(caprolactone) (PCL) fibrous matrix with gradation in tricalcium phosphate (TCP) content. PCL solution in chloroform containing TCP powders was centrifuged for inducing gradient content in TCP. The PCL solution with centrifuged TCP was electrospun into the collector, resulting in the TCP-gradient PCL fibrous matrix with a high content of TCP at the bottom and nearly zero content at the top of the matrix. Cell culture on the fibrous matrices with low and high contents confirmed that osteoblast (MC3T3-E1) favored the fibrous matrix with a high TCP content in terms of proliferation and osteogenic differentiation. The TCP-gradient PCL fibrous matrix can potentially be employed for the biomedical application to the bone and bone-to-tendon regeneration.

AB - We have demonstrated a facile method for the fabrication of biomimetic poly(caprolactone) (PCL) fibrous matrix with gradation in tricalcium phosphate (TCP) content. PCL solution in chloroform containing TCP powders was centrifuged for inducing gradient content in TCP. The PCL solution with centrifuged TCP was electrospun into the collector, resulting in the TCP-gradient PCL fibrous matrix with a high content of TCP at the bottom and nearly zero content at the top of the matrix. Cell culture on the fibrous matrices with low and high contents confirmed that osteoblast (MC3T3-E1) favored the fibrous matrix with a high TCP content in terms of proliferation and osteogenic differentiation. The TCP-gradient PCL fibrous matrix can potentially be employed for the biomedical application to the bone and bone-to-tendon regeneration.

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A facile method for preparation of polycaprolactone/tricalcium phosphate fibrous matrix with a gradient mineral content

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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