We have demonstrated a facile method for the fabrication of biomimetic poly(caprolactone) (PCL) fibrous matrix with gradation in tricalcium phosphate (TCP) content. PCL solution in chloroform containing TCP powders was centrifuged for inducing gradient content in TCP. The PCL solution with centrifuged TCP was electrospun into the collector, resulting in the TCP-gradient PCL fibrous matrix with a high content of TCP at the bottom and nearly zero content at the top of the matrix. Cell culture on the fibrous matrices with low and high contents confirmed that osteoblast (MC3T3-E1) favored the fibrous matrix with a high TCP content in terms of proliferation and osteogenic differentiation. The TCP-gradient PCL fibrous matrix can potentially be employed for the biomedical application to the bone and bone-to-tendon regeneration.
|Number of pages||8|
|Journal||Colloids and Surfaces A: Physicochemical and Engineering Aspects|
|Publication status||Published - 2013 Jul|
Bibliographical noteFunding Information:
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011-0023064 ), a grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( A110416 ), a grant from the “GRRC” Project of Gyeonggi Provincial Government, Korea , and the Research Fund, 2012 of The Catholic University of Korea .
All Science Journal Classification (ASJC) codes
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry