A feasibility study for diagnosis of latent tuberculosis infection using an IGRA point-of-care platform in South Korea

Yun Gyoung Hur, Ji Young Hong, Dong Hwan Choi, Ahreum Kim, So Yeong Park, Minsuk Kwon, Kyungjoon Kang, Jeong Min Lee, Hazel M. Dockrell, Yoonsuk Lee, Hoodon Joo, Sang Nae Cho

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3 Citations (Scopus)


Purpose: This study aimed to evaluate ichroma™ IGRA-TB, a novel point-of-care platform for assaying IFN-γ release, and to compare it with QuantiFERON-TB Gold In-Tube (QFT-GIT) for identifying Mycobacterium tuberculosis (M. tb) infection. Materials and Methods: We recruited 60 healthy subjects, and blood samples were obtained in QFT-GIT blood collection tubes. The blood collection tubes were incubated at 37ºC, and culture supernatant was harvested after 18–24 hours. IFN-γ responses were assessed by the ichroma™ IGRA-TB cartridge and the QFT-GIT IFN-γ enzyme-linked immunosorbent assay. Three active TB patients were recruited as a positive control for M. tb infection. Results: The area under the receiver operating characteristic curve of the ichroma™ IGRA-TB test for differentiating between infected and non-infected individuals was 0.9706 (p<0.001). Inconsistent positivity between the two tests was found in three participants who showed weak positive IFN-γ responses (<1.0 IU/mL) with QFT-GIT. However, the two tests had excellent agreement (95.2%, κ=0.91, p<0.001), and a very strong positive correlation was observed between the IFN-γ values of both tests (r=0.91, p<0.001). Conclusion: The diagnostic accuracy demonstrated in this study indicates that the ichroma™ IGRA-TB test could be used as a rapid diagnostic method for detecting latent TB infection. It may be particularly beneficial in resource-limited places that require cost-effective laboratory diagnostics.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalYonsei medical journal
Issue number4
Publication statusPublished - 2019 Apr

Bibliographical note

Funding Information:
Med Inc., Chuncheon, and in part by funding from the Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea. Sang-Nae Cho received a research grant from Boditech Med Inc., but claims no conflict of interest. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding Information:
This work was supported by a research grant from Boditech

Publisher Copyright:
© Yonsei University College of Medicine 2019.

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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