Abstract
Background: With improved short-term surgical outcomes, laparoscopic distal gastrectomy has rapidly gained popularity. However, the safety and feasibility of laparoscopic total gastrectomy (LTG) has not yet been proven due to the difficulty of the technique. This single-arm prospective multi-center study was conducted to evaluate the use of LTG for clinical stage I gastric cancer. Methods: Between October 2012 and January 2014, 170 patients with pathologically proven, clinical stage I gastric adenocarcinoma located at the proximal stomach were enrolled. Twenty-two experienced surgeons from 19 institutions participated in this clinical trial. The primary end point was the incidence of postoperative morbidity and mortality at postoperative 30 days. The severity of postoperative complications was categorized according to Clavien–Dindo classification, and the incidence of postoperative morbidity and mortality was compared with that in a historical control. Results: Of the enrolled patients, 160 met criteria for inclusion in the full analysis set. Postoperative morbidity and mortality rates reached 20.6% (33/160) and 0.6% (1/160), respectively. Fifteen patients (9.4%) had grade III or higher complications, and three reoperations (1.9%) were performed. The incidence of morbidity after LTG in this trial did not significantly differ from that reported in a previous study for open total gastrectomy (18%). Conclusions: LTG performed by experienced surgeons showed acceptable postoperative morbidity and mortality for patients with clinical stage I gastric cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 214-222 |
| Number of pages | 9 |
| Journal | Gastric Cancer |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 Jan 22 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Gastroenterology
- Cancer Research
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A feasibility study of laparoscopic total gastrectomy for clinical stage I gastric cancer : a prospective multi-center phase II clinical trial, KLASS 03. / Hyung, WooJin; Yang, Han Kwang; Han, Sang Uk; Lee, Young Jun; Park, Joong Min; Kim, Jin Jo; Kwon, Oh Kyung; Kong, Seong Ho; Kim, Hyoung Il; Lee, Hyuk Joon; Kim, Wook; Ryu, Seung Wan; Jin, Sung Ho; Oh, Sung Jin; Ryu, Keun Won; Kim, Min Chan; Ahn, Hye Seong; Park, Young Kyu; Kim, Young Ho; Hwang, Sun Hwi; Kim, Jong Won; Cho, Gyu Seok.
In: Gastric Cancer, Vol. 22, No. 1, 22.01.2019, p. 214-222.Research output: Contribution to journal › Article
TY - JOUR
T1 - A feasibility study of laparoscopic total gastrectomy for clinical stage I gastric cancer
T2 - a prospective multi-center phase II clinical trial, KLASS 03
AU - Hyung, WooJin
AU - Yang, Han Kwang
AU - Han, Sang Uk
AU - Lee, Young Jun
AU - Park, Joong Min
AU - Kim, Jin Jo
AU - Kwon, Oh Kyung
AU - Kong, Seong Ho
AU - Kim, Hyoung Il
AU - Lee, Hyuk Joon
AU - Kim, Wook
AU - Ryu, Seung Wan
AU - Jin, Sung Ho
AU - Oh, Sung Jin
AU - Ryu, Keun Won
AU - Kim, Min Chan
AU - Ahn, Hye Seong
AU - Park, Young Kyu
AU - Kim, Young Ho
AU - Hwang, Sun Hwi
AU - Kim, Jong Won
AU - Cho, Gyu Seok
PY - 2019/1/22
Y1 - 2019/1/22
N2 - Background: With improved short-term surgical outcomes, laparoscopic distal gastrectomy has rapidly gained popularity. However, the safety and feasibility of laparoscopic total gastrectomy (LTG) has not yet been proven due to the difficulty of the technique. This single-arm prospective multi-center study was conducted to evaluate the use of LTG for clinical stage I gastric cancer. Methods: Between October 2012 and January 2014, 170 patients with pathologically proven, clinical stage I gastric adenocarcinoma located at the proximal stomach were enrolled. Twenty-two experienced surgeons from 19 institutions participated in this clinical trial. The primary end point was the incidence of postoperative morbidity and mortality at postoperative 30 days. The severity of postoperative complications was categorized according to Clavien–Dindo classification, and the incidence of postoperative morbidity and mortality was compared with that in a historical control. Results: Of the enrolled patients, 160 met criteria for inclusion in the full analysis set. Postoperative morbidity and mortality rates reached 20.6% (33/160) and 0.6% (1/160), respectively. Fifteen patients (9.4%) had grade III or higher complications, and three reoperations (1.9%) were performed. The incidence of morbidity after LTG in this trial did not significantly differ from that reported in a previous study for open total gastrectomy (18%). Conclusions: LTG performed by experienced surgeons showed acceptable postoperative morbidity and mortality for patients with clinical stage I gastric cancer.
AB - Background: With improved short-term surgical outcomes, laparoscopic distal gastrectomy has rapidly gained popularity. However, the safety and feasibility of laparoscopic total gastrectomy (LTG) has not yet been proven due to the difficulty of the technique. This single-arm prospective multi-center study was conducted to evaluate the use of LTG for clinical stage I gastric cancer. Methods: Between October 2012 and January 2014, 170 patients with pathologically proven, clinical stage I gastric adenocarcinoma located at the proximal stomach were enrolled. Twenty-two experienced surgeons from 19 institutions participated in this clinical trial. The primary end point was the incidence of postoperative morbidity and mortality at postoperative 30 days. The severity of postoperative complications was categorized according to Clavien–Dindo classification, and the incidence of postoperative morbidity and mortality was compared with that in a historical control. Results: Of the enrolled patients, 160 met criteria for inclusion in the full analysis set. Postoperative morbidity and mortality rates reached 20.6% (33/160) and 0.6% (1/160), respectively. Fifteen patients (9.4%) had grade III or higher complications, and three reoperations (1.9%) were performed. The incidence of morbidity after LTG in this trial did not significantly differ from that reported in a previous study for open total gastrectomy (18%). Conclusions: LTG performed by experienced surgeons showed acceptable postoperative morbidity and mortality for patients with clinical stage I gastric cancer.
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U2 - 10.1007/s10120-018-0864-4
DO - 10.1007/s10120-018-0864-4
M3 - Article
VL - 22
SP - 214
EP - 222
JO - Gastric Cancer
JF - Gastric Cancer
SN - 1436-3291
IS - 1
ER -