A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells

Sang Hyun Park; Hyoje Jung; Yujun Kim; Injae Shin

doi:10.1039/d2cc01082h

A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells

Sang Hyun Park, Hyoje Jung, Yujun Kim, Injae Shin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We describe a fluorogenic probe BocLys(Ac)-AB-FC targeting both histone deacetylases (HDACs) and cathepsin l, which are overexpressed in spatially separated subcellular organelles of cancer cells. The results show that this fluorogenic probe can be used for selective cancer cell imaging without interference arising from normal cells.

Original language	English
Pages (from-to)	4079-4082
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	25
DOIs	https://doi.org/10.1039/d2cc01082h
Publication status	Published - 2022 Mar 3

Bibliographical note

Publisher Copyright:
© 2022 The Royal Society of Chemistry

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/d2cc01082h

Cite this

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abstract = "We describe a fluorogenic probe BocLys(Ac)-AB-FC targeting both histone deacetylases (HDACs) and cathepsin l, which are overexpressed in spatially separated subcellular organelles of cancer cells. The results show that this fluorogenic probe can be used for selective cancer cell imaging without interference arising from normal cells.",

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AB - We describe a fluorogenic probe BocLys(Ac)-AB-FC targeting both histone deacetylases (HDACs) and cathepsin l, which are overexpressed in spatially separated subcellular organelles of cancer cells. The results show that this fluorogenic probe can be used for selective cancer cell imaging without interference arising from normal cells.

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A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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