A fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval

Xia Lou, Jaehoon Chung, Young Ji Kim, Il Joo Cho, Euisik Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report a fully addressable micro-array chip integrated with cascade multiplexors for selective cell loading and retrieval in a stacked PDMS (polydimethylsiloxane) layers for microfluidic control. This chip provides the addressable manipulation of large number of cells at single cell resolution. A cascade multiplexer is developed to reduce the number of pneumatic control inputs integrated on chip. Hydrodynamic structures are incorporated for efficient single cell loading as well as retrieval. We have fabricated the prototype device in an 8x8 array and demonstrated the feasibility of single cell manipulation. We have loaded and cultured C2C12 cells in the prototype chip and then successfully retrieved the viable cells.

Original languageEnglish
Title of host publicationTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages1301-1304
Number of pages4
DOIs
Publication statusPublished - 2009
EventTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States
Duration: 2009 Jun 212009 Jun 25

Publication series

NameTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

OtherTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
CountryUnited States
CityDenver, CO
Period09/6/2109/6/25

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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