A gene × gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males

Kevin M. Beaver, John Paul Wright, Matt DeLisi, Anthony Walsh, Michael George Vaughn, Danielle Boisvert, Jamie Vaske

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Background: Antisocial behaviors are complex polygenic phenotypes that are due to a multifactorial arrangement of genetic polymorphisms. Little empirical research, however, has been undertaken that examines gene × gene interactions in the etiology of conduct disorder and antisocial behavior. This study examined whether adolescent conduct disorder and adult antisocial behavior were related to the dopamine D2 receptor polymorphism (DRD2) and the dopamine D4 receptor polymorphism (DRD4). Methods: A sample of 872 male participants from the National Longitudinal Study of Adolescent Health (Add Health) completed self-report questionnaires that tapped adolescent conduct disorder and adult antisocial behavior. DNA was genotyped for DRD2 and DRD4. Results: Multivariate regression analysis revealed that neither DRD2 nor DRD4 had significant independent effects on conduct disorder or antisocial behavior. However, DRD2 interacted with DRD4 to predict variation in adolescent conduct disorder and in adult antisocial behavior. Conclusion: The results suggest that a gene × gene interaction between DRD2 and DRD4 is associated with the development of conduct disorder and adult antisocial behavior in males.

Original languageEnglish
Article number30
JournalBehavioral and Brain Functions
Volume3
DOIs
Publication statusPublished - 2007 Jun 22

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Conduct Disorder
Genes
National Longitudinal Study of Adolescent Health
Dopamine D4 Receptors
Empirical Research
Dopamine D2 Receptors
Genetic Polymorphisms
Self Report
Multivariate Analysis
Regression Analysis
Phenotype
DNA
Health

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Beaver, Kevin M. ; Wright, John Paul ; DeLisi, Matt ; Walsh, Anthony ; Vaughn, Michael George ; Boisvert, Danielle ; Vaske, Jamie. / A gene × gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males. In: Behavioral and Brain Functions. 2007 ; Vol. 3.
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A gene × gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males. / Beaver, Kevin M.; Wright, John Paul; DeLisi, Matt; Walsh, Anthony; Vaughn, Michael George; Boisvert, Danielle; Vaske, Jamie.

In: Behavioral and Brain Functions, Vol. 3, 30, 22.06.2007.

Research output: Contribution to journalArticle

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AU - Vaske, Jamie

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