A hierarchical cluster analysis of normal-tension glaucoma using spectral-domain optical coherence tomography parameters

Hyoung Won Bae, Yongwoo Ji, Hye Sun Lee, Naeun Lee, Samin Hong, Gong Je Seong, Kyung Rim Sung, Chan Yun Kim

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4 Citations (Scopus)


Purpose: Normal-tension glaucoma (NTG) is a heterogenous disease, and there is still controversy about subclassifications of this disorder. On the basis of spectral-domain optical coherence tomography (SD-OCT), we subdivided NTG with hierarchical cluster analysis using optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thicknesses. Patients and Methods: A total of 200 eyes of 200 NTG patients between March 2011 and June 2012 underwent SD-OCT scans to measure ONH parameters and RNFL thicknesses. We classified NTG into homogenous subgroups based on these variables using a hierarchical cluster analysis, and compared clusters to evaluate diverse NTG characteristics. Results: Three clusters were found after hierarchical cluster analysis. Cluster 1 (62 eyes) had the thickest RNFL and widest rim area, and showed early glaucoma features. Cluster 2 (60 eyes) was characterized by the largest cup/disc ratio and cup volume, and showed advanced glaucomatous damage. Cluster 3 (78 eyes) had small disc areas in SD-OCT and were comprised of patients with significantly younger age, longer axial length, and greater myopia than the other 2 groups. Conclusions: A hierarchical cluster analysis of SD-OCT scans divided NTG patients into 3 groups based upon ONH parameters and RNFL thicknesses. It is anticipated that the small disc area group comprised of younger and more myopic patients may show unique features unlike the other 2 groups.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalJournal of Glaucoma
Issue number4
Publication statusPublished - 2015 Apr 17


All Science Journal Classification (ASJC) codes

  • Ophthalmology

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