A Highly Sensitive Amperometric Galactose Biosensor Based on Graphene-doped Sol-gel-derived Titania-Nafion Composite Films

Sumin Lee; Daeho Jeong; Sangjung Lee; Sungju Nam; Won Yong Lee

doi:10.1002/elan.202100357

A Highly Sensitive Amperometric Galactose Biosensor Based on Graphene-doped Sol-gel-derived Titania-Nafion Composite Films

Sumin Lee, Daeho Jeong, Sangjung Lee, Sungju Nam, Won Yong Lee

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A highly sensitive amperometric galactose biosensor was developed by encapsulating galactose oxidase within the graphene-doped sol-gel titania-Nafion composite film on platinized glassy carbon electrode. Due to the combined electrocatalytic activity of graphene and Pt NPs on the electrode towards hydrogen peroxide as well as the mesoporous nature of the titania-Nafion composite, the present galactose biosensor exhibited relatively fast response time under 2 s, high sensitivity of 40.6 mAM⁻¹cm⁻², and wide dynamic range over three orders of magnitude with a detection limit of 3.78×10⁻⁶ M (S/N=3). In addition, the biocompatible composite in the biosensor secures excellent long-term stability.

Original language	English
Pages (from-to)	629-639
Number of pages	11
Journal	Electroanalysis
Volume	34
Issue number	4
DOIs	https://doi.org/10.1002/elan.202100357
Publication status	Published - 2022 Apr

Bibliographical note

Funding Information:
Financial support for this work has been provided by Basic Science Research Program through the National Research Foundation of Korea (NRF‐2018R1D1A1A09082076) funded by the Ministry of Education, Science and Technology.

Publisher Copyright:
© 2021 Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Electrochemistry

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title = "A Highly Sensitive Amperometric Galactose Biosensor Based on Graphene-doped Sol-gel-derived Titania-Nafion Composite Films",

abstract = "A highly sensitive amperometric galactose biosensor was developed by encapsulating galactose oxidase within the graphene-doped sol-gel titania-Nafion composite film on platinized glassy carbon electrode. Due to the combined electrocatalytic activity of graphene and Pt NPs on the electrode towards hydrogen peroxide as well as the mesoporous nature of the titania-Nafion composite, the present galactose biosensor exhibited relatively fast response time under 2 s, high sensitivity of 40.6 mAM−1cm−2, and wide dynamic range over three orders of magnitude with a detection limit of 3.78×10−6 M (S/N=3). In addition, the biocompatible composite in the biosensor secures excellent long-term stability.",

author = "Sumin Lee and Daeho Jeong and Sangjung Lee and Sungju Nam and Lee, {Won Yong}",

note = "Funding Information: Financial support for this work has been provided by Basic Science Research Program through the National Research Foundation of Korea (NRF‐2018R1D1A1A09082076) funded by the Ministry of Education, Science and Technology. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH.",

year = "2022",

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AU - Jeong, Daeho

AU - Lee, Sangjung

AU - Nam, Sungju

AU - Lee, Won Yong

N1 - Funding Information: Financial support for this work has been provided by Basic Science Research Program through the National Research Foundation of Korea (NRF‐2018R1D1A1A09082076) funded by the Ministry of Education, Science and Technology. Publisher Copyright: © 2021 Wiley-VCH GmbH.

PY - 2022/4

Y1 - 2022/4

N2 - A highly sensitive amperometric galactose biosensor was developed by encapsulating galactose oxidase within the graphene-doped sol-gel titania-Nafion composite film on platinized glassy carbon electrode. Due to the combined electrocatalytic activity of graphene and Pt NPs on the electrode towards hydrogen peroxide as well as the mesoporous nature of the titania-Nafion composite, the present galactose biosensor exhibited relatively fast response time under 2 s, high sensitivity of 40.6 mAM−1cm−2, and wide dynamic range over three orders of magnitude with a detection limit of 3.78×10−6 M (S/N=3). In addition, the biocompatible composite in the biosensor secures excellent long-term stability.

AB - A highly sensitive amperometric galactose biosensor was developed by encapsulating galactose oxidase within the graphene-doped sol-gel titania-Nafion composite film on platinized glassy carbon electrode. Due to the combined electrocatalytic activity of graphene and Pt NPs on the electrode towards hydrogen peroxide as well as the mesoporous nature of the titania-Nafion composite, the present galactose biosensor exhibited relatively fast response time under 2 s, high sensitivity of 40.6 mAM−1cm−2, and wide dynamic range over three orders of magnitude with a detection limit of 3.78×10−6 M (S/N=3). In addition, the biocompatible composite in the biosensor secures excellent long-term stability.

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A Highly Sensitive Amperometric Galactose Biosensor Based on Graphene-doped Sol-gel-derived Titania-Nafion Composite Films

Abstract

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All Science Journal Classification (ASJC) codes

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