A large, nationwide, longitudinal study of central nervous system diseases among Korean workers exposed to manganese

JinHa Yoon, Yeon Soon Ahn

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: In occupational epidemiologic studies, the low incidence and chronic process of central nervous system (CNS) diseases has complicated the determination of the relationship between increased morbidity and manganese (Mn) exposure. Therefore, through this large cohort study, we evaluated CNS disease morbidity among Korean workers exposed to Mn. Methods: Data were collected from Mn-associated specialized medical check-up 2000 and 2004 in Korea. The number of workers admitted to hospital because of clinically diagnosed CNS disease was analyzed in male workers exposed to Mn (n=104,544). As a control reference population, 2% of Korean men were randomly selected and their hospital admission data were analyzed. For Mn-exposed workers, Standardized admission ratios (SARs) for CNS disease, as determined by ICD-10 classifications, were estimated in reference to the control population. Results: During follow up, 64 workers admitted because of CNS diseases. Chronic exposure to Mn (≥10 years) was significantly associated with the SAR (95% CI) of extrapyramidal and movement disorders (SAR: 2.03, 95% CI: 1.05-3.55), in particular, other extrapyramidal and movement disorders (SAR: 4.81, 95% CI: 1.29-12.32). Also borderline association (SAR=4.88, 90% CI: 1.05-7.04) was noted for secondary Parkinsonism among workers with chronic Mn exposure. SARs (95% CI) for other degenerative nervous system diseases were significantly higher in Mn-exposed workers compared with the control population (SAR: 3.60, 95% CI: 1.16-8.40). Conclusion: In conclusion, Mn-exposed workers exhibited significantly elevated SARs for degenerative nervous system diseases and extrapyramidal and movement disorders, compared to the age-matched reference population, suggesting a relatedness with Mn exposure.

Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalParkinsonism and Related Disorders
Volume21
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1

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Central Nervous System Diseases
Manganese
Longitudinal Studies
Basal Ganglia Diseases
Movement Disorders
Neurodegenerative Diseases
Population
Secondary Parkinson Disease
Morbidity
International Classification of Diseases
Korea
Epidemiologic Studies
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

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abstract = "Introduction: In occupational epidemiologic studies, the low incidence and chronic process of central nervous system (CNS) diseases has complicated the determination of the relationship between increased morbidity and manganese (Mn) exposure. Therefore, through this large cohort study, we evaluated CNS disease morbidity among Korean workers exposed to Mn. Methods: Data were collected from Mn-associated specialized medical check-up 2000 and 2004 in Korea. The number of workers admitted to hospital because of clinically diagnosed CNS disease was analyzed in male workers exposed to Mn (n=104,544). As a control reference population, 2{\%} of Korean men were randomly selected and their hospital admission data were analyzed. For Mn-exposed workers, Standardized admission ratios (SARs) for CNS disease, as determined by ICD-10 classifications, were estimated in reference to the control population. Results: During follow up, 64 workers admitted because of CNS diseases. Chronic exposure to Mn (≥10 years) was significantly associated with the SAR (95{\%} CI) of extrapyramidal and movement disorders (SAR: 2.03, 95{\%} CI: 1.05-3.55), in particular, other extrapyramidal and movement disorders (SAR: 4.81, 95{\%} CI: 1.29-12.32). Also borderline association (SAR=4.88, 90{\%} CI: 1.05-7.04) was noted for secondary Parkinsonism among workers with chronic Mn exposure. SARs (95{\%} CI) for other degenerative nervous system diseases were significantly higher in Mn-exposed workers compared with the control population (SAR: 3.60, 95{\%} CI: 1.16-8.40). Conclusion: In conclusion, Mn-exposed workers exhibited significantly elevated SARs for degenerative nervous system diseases and extrapyramidal and movement disorders, compared to the age-matched reference population, suggesting a relatedness with Mn exposure.",
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A large, nationwide, longitudinal study of central nervous system diseases among Korean workers exposed to manganese. / Yoon, JinHa; Ahn, Yeon Soon.

In: Parkinsonism and Related Disorders, Vol. 21, No. 3, 01.01.2015, p. 194-198.

Research output: Contribution to journalArticle

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AB - Introduction: In occupational epidemiologic studies, the low incidence and chronic process of central nervous system (CNS) diseases has complicated the determination of the relationship between increased morbidity and manganese (Mn) exposure. Therefore, through this large cohort study, we evaluated CNS disease morbidity among Korean workers exposed to Mn. Methods: Data were collected from Mn-associated specialized medical check-up 2000 and 2004 in Korea. The number of workers admitted to hospital because of clinically diagnosed CNS disease was analyzed in male workers exposed to Mn (n=104,544). As a control reference population, 2% of Korean men were randomly selected and their hospital admission data were analyzed. For Mn-exposed workers, Standardized admission ratios (SARs) for CNS disease, as determined by ICD-10 classifications, were estimated in reference to the control population. Results: During follow up, 64 workers admitted because of CNS diseases. Chronic exposure to Mn (≥10 years) was significantly associated with the SAR (95% CI) of extrapyramidal and movement disorders (SAR: 2.03, 95% CI: 1.05-3.55), in particular, other extrapyramidal and movement disorders (SAR: 4.81, 95% CI: 1.29-12.32). Also borderline association (SAR=4.88, 90% CI: 1.05-7.04) was noted for secondary Parkinsonism among workers with chronic Mn exposure. SARs (95% CI) for other degenerative nervous system diseases were significantly higher in Mn-exposed workers compared with the control population (SAR: 3.60, 95% CI: 1.16-8.40). Conclusion: In conclusion, Mn-exposed workers exhibited significantly elevated SARs for degenerative nervous system diseases and extrapyramidal and movement disorders, compared to the age-matched reference population, suggesting a relatedness with Mn exposure.

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