A Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long-Term Signal Recording

Yeontaek Lee, Hyogeun Shin, Dongwon Lee, Sungah Choi, Il Joo Cho, Jungmok Seo

Research output: Contribution to journalArticlepeer-review

Abstract

Brain-machine interfaces (BMIs) that link the brain to a machine are promising for the treatment of neurological disorders through the bi-directional translation of neural information over extended periods. However, the longevity of such implanted devices remains limited by the deterioration of their signal sensitivity over time due to acute inflammation from insertion trauma and chronic inflammation caused by the foreign body reaction. To address this challenge, a lubricated surface is fabricated to minimize friction during insertion and avoid immunogenicity during neural signal recording. Reduced friction force leads to 86% less impulse on the brain tissue, and thus immediately increases the number of measured signal electrodes by 102% upon insertion. Furthermore, the signal measurable period increases from 8 to 16 weeks due to the prevention of gliosis. By significantly reducing insertion damage and the foreign body reaction, the lubricated immune-stealthy probe surface (LIPS) can maximize the longevity of implantable BMIs.

Original languageEnglish
JournalAdvanced Science
DOIs
Publication statusAccepted/In press - 2021

Bibliographical note

Funding Information:
Y.L. and H.S. contributed equally to this work. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF‐2019R1C1C1006720, 2021M3H4A1A03048648), the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (Project Number: 9991006804, KMDF_PR_20200901_0131), (Project Number: 9991007124, KMDF_PR_20200901_0039). This work was also supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIT) (NRF‐2017M3C7A1028854).

Publisher Copyright:
© 2021 The Authors. Advanced Science published by Wiley-VCH GmbH

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Engineering(all)
  • Physics and Astronomy(all)

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