A mechanism of adsorption of β-nicotinamide adenine dinucleotide on graphene sheets

Experiment and theory

Martin Pumera, Roberto Scipioni, Hideo Iwai, Takahisa Ohno, Yuji Miyahara, Mauro Boero

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

β-Nicotinamide adenine dinucleotide (NAD+) and its reduced form (NADH) play major roles in the development of electrochemical enzyme biosensors and biofuel cells. Unfortunately, the oxidation of NADH at carbon electrodes suffers from passivation of the electrodes and a decrease in passing currents. Here, we investigate experimentally and theoretically the reasons for such passivation. Highresolution X-ray photoelectron spectroscopy (HR-XPS), voltammetry, and amperometry show that adsorption occurs on the edges and "edge-like" defects of graphene sheets. HR-XPS and ab initio molecular dynamics show that the adsorption of NAD+ molecules on the edges of graphene happens due to interaction with oxygencontaining groups such as carboxylic groups, while graphene edges substituted only with hydrogen are prone to passivation.

Original languageEnglish
Pages (from-to)10851-10856
Number of pages6
JournalChemistry - A European Journal
Volume15
Issue number41
DOIs
Publication statusPublished - 2009 Oct 19

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Graphite
Passivation
NAD
Graphene
Adsorption
X ray photoelectron spectroscopy
Biological fuel cells
Electrodes
Experiments
Voltammetry
Biosensors
Molecular dynamics
Enzymes
Oxidation
Hydrogen
Defects
Molecules
Carbon

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Pumera, Martin ; Scipioni, Roberto ; Iwai, Hideo ; Ohno, Takahisa ; Miyahara, Yuji ; Boero, Mauro. / A mechanism of adsorption of β-nicotinamide adenine dinucleotide on graphene sheets : Experiment and theory. In: Chemistry - A European Journal. 2009 ; Vol. 15, No. 41. pp. 10851-10856.
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A mechanism of adsorption of β-nicotinamide adenine dinucleotide on graphene sheets : Experiment and theory. / Pumera, Martin; Scipioni, Roberto; Iwai, Hideo; Ohno, Takahisa; Miyahara, Yuji; Boero, Mauro.

In: Chemistry - A European Journal, Vol. 15, No. 41, 19.10.2009, p. 10851-10856.

Research output: Contribution to journalArticle

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AU - Pumera, Martin

AU - Scipioni, Roberto

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AB - β-Nicotinamide adenine dinucleotide (NAD+) and its reduced form (NADH) play major roles in the development of electrochemical enzyme biosensors and biofuel cells. Unfortunately, the oxidation of NADH at carbon electrodes suffers from passivation of the electrodes and a decrease in passing currents. Here, we investigate experimentally and theoretically the reasons for such passivation. Highresolution X-ray photoelectron spectroscopy (HR-XPS), voltammetry, and amperometry show that adsorption occurs on the edges and "edge-like" defects of graphene sheets. HR-XPS and ab initio molecular dynamics show that the adsorption of NAD+ molecules on the edges of graphene happens due to interaction with oxygencontaining groups such as carboxylic groups, while graphene edges substituted only with hydrogen are prone to passivation.

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