A Meta-Analysis of Nonpharmacological Interventions for People With Parkinson’s Disease

Ju Hee Lee, Moon Ki Choi, Yonju Yoo

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10 Citations (Scopus)


Nonpharmacological interventions are important in providing care for Parkinson’s disease (PD) patients. However, there is limited evidence related to their impacts on health-related quality of life (HRQOL). We aimed to examine the effectiveness of nonpharmacological interventions for improving the HRQOL of PD patients. Articles published in peer-reviewed journals from 2000 to 2015 were searched through electronic searching, computerized author searching, and footnote chasing. A meta-analysis was performed using the RevMan 5.3 program. Overall, effect size for the studies (n = 18) was −4.17 with 95% confidence interval (CI) from −7.63 to −0.70 (Z = 2.36, p =.02), indicating positive effects of nonpharmacological interventions on HRQOL. In subgroup analysis regarding the intervention types, the effect size of exercise programs was −5.73 with 95% CI of −11.36 to −0.10 (Z = 2.00, p =.05). Thus, nonpharmacological interventions, and particularly exercise programs, were effective in improving the HRQOL of PD patients.

Original languageEnglish
Pages (from-to)608-631
Number of pages24
JournalClinical Nursing Research
Issue number5
Publication statusPublished - 2017 Oct 1

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (NRF-2012R1A1A3012645).

Publisher Copyright:
© 2016, © The Author(s) 2016.

All Science Journal Classification (ASJC) codes

  • Nursing(all)


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