Acid bromides were prepared efficiently from carboxylic acids with readily available ethyl tribromoacetate and triphenylphosphine at room temperature under neutral conditions. The present process is applicable to the preparation of various acid bromides from aromatic and aliphatic carboxylic acids. Aromatic carboxylic acids were found to be more reactive than aliphatic carboxylic acids under reaction conditions.
Bibliographical noteFunding Information:
This work was supported by Joint Research Project under the KOSEF-NRCT cooperative program (F01-2004-000-10252-0) and CBMH.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry