A mild and efficient reaction for conversion of carboxylic acids into acid bromides with ethyl tribromoacetate/triphenylphosphine under acid-free conditions

Dong Ho Kang, Tae Young Joo, Eun Hwa Lee, Skaydaw Chaysripongkul, Warinthorn Chavasiri, Doo Ok Jang

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Acid bromides were prepared efficiently from carboxylic acids with readily available ethyl tribromoacetate and triphenylphosphine at room temperature under neutral conditions. The present process is applicable to the preparation of various acid bromides from aromatic and aliphatic carboxylic acids. Aromatic carboxylic acids were found to be more reactive than aliphatic carboxylic acids under reaction conditions.

Original languageEnglish
Pages (from-to)5693-5696
Number of pages4
JournalTetrahedron Letters
Issue number32
Publication statusPublished - 2006 Aug 7


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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