A miniature headstage for high resolution closed-loop optogenetics

Adam E. Mendrela, Kanghwan Kim, Daniel English, Sam McKenzie, John Seymour, György Buzsáki, Euisik Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We present a novel integrated miniature headstage for high-density closed-loop optogenetics studies with the highest published channel count to date. The headstage performs optical stimulation and electrical neural recording through a monolithically integrated electrode with 12 or 32 μLEDs and 32 recording sites. The electronic back-end consists of a custom 48-channel LED driver IC capable of real-time individual channel control at 10-bit optical power precision and a 32-channel off-the-shelf neural recording IC. The system's functionality was proven in vivo through high-precision neuronal stimulation in a mouse hippocampus.

Original languageEnglish
Title of host publication2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1-4
Number of pages4
ISBN (Electronic)9781509058037
DOIs
Publication statusPublished - 2018 Mar 23
Event2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Torino, Italy
Duration: 2017 Oct 192017 Oct 21

Publication series

Name2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
Volume2018-January

Other

Other2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017
CountryItaly
CityTorino
Period17/10/1917/10/21

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Instrumentation

Cite this

Mendrela, A. E., Kim, K., English, D., McKenzie, S., Seymour, J., Buzsáki, G., & Yoon, E. (2018). A miniature headstage for high resolution closed-loop optogenetics. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings (pp. 1-4). (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings; Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIOCAS.2017.8325187