A miniature headstage for high resolution closed-loop optogenetics

Adam E. Mendrela, Kanghwan Kim, Daniel English, Sam McKenzie, John Seymour, György Buzsáki, Euisik Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We present a novel integrated miniature headstage for high-density closed-loop optogenetics studies with the highest published channel count to date. The headstage performs optical stimulation and electrical neural recording through a monolithically integrated electrode with 12 or 32 μLEDs and 32 recording sites. The electronic back-end consists of a custom 48-channel LED driver IC capable of real-time individual channel control at 10-bit optical power precision and a 32-channel off-the-shelf neural recording IC. The system's functionality was proven in vivo through high-precision neuronal stimulation in a mouse hippocampus.

Original languageEnglish
Title of host publication2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1-4
Number of pages4
ISBN (Electronic)9781509058037
DOIs
Publication statusPublished - 2018 Mar 23
Event2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Torino, Italy
Duration: 2017 Oct 192017 Oct 21

Publication series

Name2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
Volume2018-January

Other

Other2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017
CountryItaly
CityTorino
Period17/10/1917/10/21

Fingerprint

Light emitting diodes
high resolution
recording
stimulation
light emitting diodes
hippocampus
Electrodes
shelves
mice
electrodes
electronics

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Instrumentation

Cite this

Mendrela, A. E., Kim, K., English, D., McKenzie, S., Seymour, J., Buzsáki, G., & Yoon, E. (2018). A miniature headstage for high resolution closed-loop optogenetics. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings (pp. 1-4). (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings; Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIOCAS.2017.8325187
Mendrela, Adam E. ; Kim, Kanghwan ; English, Daniel ; McKenzie, Sam ; Seymour, John ; Buzsáki, György ; Yoon, Euisik. / A miniature headstage for high resolution closed-loop optogenetics. 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 1-4 (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings).
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Mendrela, AE, Kim, K, English, D, McKenzie, S, Seymour, J, Buzsáki, G & Yoon, E 2018, A miniature headstage for high resolution closed-loop optogenetics. in 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings, vol. 2018-January, Institute of Electrical and Electronics Engineers Inc., pp. 1-4, 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017, Torino, Italy, 17/10/19. https://doi.org/10.1109/BIOCAS.2017.8325187

A miniature headstage for high resolution closed-loop optogenetics. / Mendrela, Adam E.; Kim, Kanghwan; English, Daniel; McKenzie, Sam; Seymour, John; Buzsáki, György; Yoon, Euisik.

2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. p. 1-4 (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings; Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Mendrela AE, Kim K, English D, McKenzie S, Seymour J, Buzsáki G et al. A miniature headstage for high resolution closed-loop optogenetics. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2018. p. 1-4. (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings). https://doi.org/10.1109/BIOCAS.2017.8325187