We present a novel integrated miniature headstage for high-density closed-loop optogenetics studies with the highest published channel count to date. The headstage performs optical stimulation and electrical neural recording through a monolithically integrated electrode with 12 or 32 μLEDs and 32 recording sites. The electronic back-end consists of a custom 48-channel LED driver IC capable of real-time individual channel control at 10-bit optical power precision and a 32-channel off-the-shelf neural recording IC. The system's functionality was proven in vivo through high-precision neuronal stimulation in a mouse hippocampus.
|Title of host publication||2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings|
|Publisher||Institute of Electrical and Electronics Engineers Inc.|
|Number of pages||4|
|Publication status||Published - 2018 Mar 23|
|Event||2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Torino, Italy|
Duration: 2017 Oct 19 → 2017 Oct 21
|Name||2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings|
|Other||2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017|
|Period||17/10/19 → 17/10/21|
Bibliographical noteFunding Information:
ACKNOWLEDGMENTS This work has been supported in part by NIH R21-EB019221 and in part by NSF 1545858. We would also like to thank Sagnik Dam for help with headstage PCB design.
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Electrical and Electronic Engineering