A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

Anil Belur Nagaraj; Peronne Joseph; Erin Ponting; Yuriy Fedorov; Salendra Singh; Alex Cole; Woncheol Lee; Euisik Yoon; Alessia Baccarini; Peter Scacheri; Ronald Buckanovich; Drew J. Adams; Ronny Drapkin; Brian D. Brown; Analisa DiFeo

doi:10.1016/j.stemcr.2018.12.002

A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

Anil Belur Nagaraj, Peronne Joseph, Erin Ponting, Yuriy Fedorov, Salendra Singh, Alex Cole, Woncheol Lee, Euisik Yoon, Alessia Baccarini, Peter Scacheri, Ronald Buckanovich, Drew J. Adams, Ronny Drapkin, Brian D. Brown, Analisa DiFeo

Yonsei Advanced Science Institute

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

In this article, DiFeo and colleagues have utilized a miRNA 3′ UTR biosensor to study tumor-initiating cells in ovarian cancer and develop a high-throughput platform to uncover miRNA-targeting drugs. They have identified miR-181a as a potent driver of tumor initiation, which can be regulated by BET inhibitors, thus introducing a previously unknown biomarker for these drugs.

Original language	English
Pages (from-to)	122-134
Number of pages	13
Journal	Stem Cell Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/j.stemcr.2018.12.002
Publication status	Published - 2019 Jan 8

All Science Journal Classification (ASJC) codes

Biochemistry
Genetics
Developmental Biology
Cell Biology

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10.1016/j.stemcr.2018.12.002

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Belur Nagaraj, A., Joseph, P., Ponting, E., Fedorov, Y., Singh, S., Cole, A., Lee, W., Yoon, E., Baccarini, A., Scacheri, P., Buckanovich, R., Adams, D. J., Drapkin, R., Brown, B. D., & DiFeo, A. (2019). A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs. Stem Cell Reports, 12(1), 122-134. https://doi.org/10.1016/j.stemcr.2018.12.002

Belur Nagaraj, Anil ; Joseph, Peronne ; Ponting, Erin ; Fedorov, Yuriy ; Singh, Salendra ; Cole, Alex ; Lee, Woncheol ; Yoon, Euisik ; Baccarini, Alessia ; Scacheri, Peter ; Buckanovich, Ronald ; Adams, Drew J. ; Drapkin, Ronny ; Brown, Brian D. ; DiFeo, Analisa. / A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs. In: Stem Cell Reports. 2019 ; Vol. 12, No. 1. pp. 122-134.

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abstract = "In this article, DiFeo and colleagues have utilized a miRNA 3′ UTR biosensor to study tumor-initiating cells in ovarian cancer and develop a high-throughput platform to uncover miRNA-targeting drugs. They have identified miR-181a as a potent driver of tumor initiation, which can be regulated by BET inhibitors, thus introducing a previously unknown biomarker for these drugs.",

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Belur Nagaraj, A, Joseph, P, Ponting, E, Fedorov, Y, Singh, S, Cole, A, Lee, W, Yoon, E, Baccarini, A, Scacheri, P, Buckanovich, R, Adams, DJ, Drapkin, R, Brown, BD & DiFeo, A 2019, 'A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs', Stem Cell Reports, vol. 12, no. 1, pp. 122-134. https://doi.org/10.1016/j.stemcr.2018.12.002

A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs. / Belur Nagaraj, Anil; Joseph, Peronne; Ponting, Erin; Fedorov, Yuriy; Singh, Salendra; Cole, Alex; Lee, Woncheol; Yoon, Euisik; Baccarini, Alessia; Scacheri, Peter; Buckanovich, Ronald; Adams, Drew J.; Drapkin, Ronny; Brown, Brian D.; DiFeo, Analisa.

In: Stem Cell Reports, Vol. 12, No. 1, 08.01.2019, p. 122-134.

Research output: Contribution to journal › Article

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