A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

Anil Belur Nagaraj, Peronne Joseph, Erin Ponting, Yuriy Fedorov, Salendra Singh, Alex Cole, Woncheol Lee, Euisik Yoon, Alessia Baccarini, Peter Scacheri, Ronald Buckanovich, Drew J. Adams, Ronny Drapkin, Brian D. Brown, Analisa DiFeo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this article, DiFeo and colleagues have utilized a miRNA 3′ UTR biosensor to study tumor-initiating cells in ovarian cancer and develop a high-throughput platform to uncover miRNA-targeting drugs. They have identified miR-181a as a potent driver of tumor initiation, which can be regulated by BET inhibitors, thus introducing a previously unknown biomarker for these drugs.

Original languageEnglish
Pages (from-to)122-134
Number of pages13
JournalStem Cell Reports
Volume12
Issue number1
DOIs
Publication statusPublished - 2019 Jan 8

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs'. Together they form a unique fingerprint.

  • Cite this

    Belur Nagaraj, A., Joseph, P., Ponting, E., Fedorov, Y., Singh, S., Cole, A., Lee, W., Yoon, E., Baccarini, A., Scacheri, P., Buckanovich, R., Adams, D. J., Drapkin, R., Brown, B. D., & DiFeo, A. (2019). A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs. Stem Cell Reports, 12(1), 122-134. https://doi.org/10.1016/j.stemcr.2018.12.002