A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea

Jinsil Seong, Ik Jae Lee, Su Jung Shim, Do Hoon Lim, Tae Hyun Kim, Jong Hoon Kim, Hong Seok Jang, Mi Sook Kim, Eui Kyu Chie, Jin Hee Kim, Taek Keun Nam, Hyung Sik Lee, Chul Joo Han

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Aim: To determine the national practice processes of care and outcomes of radiotherapy for hepatocellular carcinoma (HCC) in Korea. Patients and Methods: A national survey of 53 institutions nationwide was conducted by requesting data on their experience of radiotherapy for HCC. Among them, 10 institutions were selected for performing more detailed analysis, based on the radiotherapy experience of at least five HCC patients between 2004 and 2005. Results: This study covered the treatment of 398 HCC patients for 2 years. Most patients (78%) were in stage III or IV. Radiotherapy was chosen after the failure of other treatments, most frequently transarterial chemoembolization. Radiotherapy was performed predominantly using the three-dimensional conformal technique (3D-CRT, 81.9%) mostly with a total dose of ≥45Gy. In 9.3% of the patients, radiotherapy was performed using radiosurgery. In a biologically effective dose (BED) with 10Gy of α/β, 4.2-124.3Gy 10 was delivered. The median survival time was 12 months, and the 2-year overall survival rate was 27.9%. A tumour size <5 cm, a negative lymph node and BED >53.1Gy 10 were shown by multivariate analysis to be significant factors for a better prognosis. In a subset analysis for the 326 patients treated with 3D-CRT, better liver function with Child-Pugh class A was shown to be an additional factor for a better prognosis. Conclusions: Radiotherapy has been used to treat advanced HCC in various modes, but mostly as a salvage treatment. Although this study was retrospective, it indicates that radiotherapy is a quite effective modality for HCC patients.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalLiver International
Volume29
Issue number2
DOIs
Publication statusPublished - 2009 Jan 19

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Physicians' Practice Patterns
Korea
Hepatocellular Carcinoma
Cohort Studies
Radiotherapy
Retrospective Studies
Salvage Therapy
Radiosurgery
Treatment Failure
Multivariate Analysis
Survival Rate
Survival

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Seong, Jinsil ; Lee, Ik Jae ; Shim, Su Jung ; Lim, Do Hoon ; Kim, Tae Hyun ; Kim, Jong Hoon ; Jang, Hong Seok ; Kim, Mi Sook ; Chie, Eui Kyu ; Kim, Jin Hee ; Nam, Taek Keun ; Lee, Hyung Sik ; Han, Chul Joo. / A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea. In: Liver International. 2009 ; Vol. 29, No. 2. pp. 147-152.
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title = "A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea",
abstract = "Aim: To determine the national practice processes of care and outcomes of radiotherapy for hepatocellular carcinoma (HCC) in Korea. Patients and Methods: A national survey of 53 institutions nationwide was conducted by requesting data on their experience of radiotherapy for HCC. Among them, 10 institutions were selected for performing more detailed analysis, based on the radiotherapy experience of at least five HCC patients between 2004 and 2005. Results: This study covered the treatment of 398 HCC patients for 2 years. Most patients (78{\%}) were in stage III or IV. Radiotherapy was chosen after the failure of other treatments, most frequently transarterial chemoembolization. Radiotherapy was performed predominantly using the three-dimensional conformal technique (3D-CRT, 81.9{\%}) mostly with a total dose of ≥45Gy. In 9.3{\%} of the patients, radiotherapy was performed using radiosurgery. In a biologically effective dose (BED) with 10Gy of α/β, 4.2-124.3Gy 10 was delivered. The median survival time was 12 months, and the 2-year overall survival rate was 27.9{\%}. A tumour size <5 cm, a negative lymph node and BED >53.1Gy 10 were shown by multivariate analysis to be significant factors for a better prognosis. In a subset analysis for the 326 patients treated with 3D-CRT, better liver function with Child-Pugh class A was shown to be an additional factor for a better prognosis. Conclusions: Radiotherapy has been used to treat advanced HCC in various modes, but mostly as a salvage treatment. Although this study was retrospective, it indicates that radiotherapy is a quite effective modality for HCC patients.",
author = "Jinsil Seong and Lee, {Ik Jae} and Shim, {Su Jung} and Lim, {Do Hoon} and Kim, {Tae Hyun} and Kim, {Jong Hoon} and Jang, {Hong Seok} and Kim, {Mi Sook} and Chie, {Eui Kyu} and Kim, {Jin Hee} and Nam, {Taek Keun} and Lee, {Hyung Sik} and Han, {Chul Joo}",
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Seong, J, Lee, IJ, Shim, SJ, Lim, DH, Kim, TH, Kim, JH, Jang, HS, Kim, MS, Chie, EK, Kim, JH, Nam, TK, Lee, HS & Han, CJ 2009, 'A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea', Liver International, vol. 29, no. 2, pp. 147-152. https://doi.org/10.1111/j.1478-3231.2008.01873.x

A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea. / Seong, Jinsil; Lee, Ik Jae; Shim, Su Jung; Lim, Do Hoon; Kim, Tae Hyun; Kim, Jong Hoon; Jang, Hong Seok; Kim, Mi Sook; Chie, Eui Kyu; Kim, Jin Hee; Nam, Taek Keun; Lee, Hyung Sik; Han, Chul Joo.

In: Liver International, Vol. 29, No. 2, 19.01.2009, p. 147-152.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea

AU - Seong, Jinsil

AU - Lee, Ik Jae

AU - Shim, Su Jung

AU - Lim, Do Hoon

AU - Kim, Tae Hyun

AU - Kim, Jong Hoon

AU - Jang, Hong Seok

AU - Kim, Mi Sook

AU - Chie, Eui Kyu

AU - Kim, Jin Hee

AU - Nam, Taek Keun

AU - Lee, Hyung Sik

AU - Han, Chul Joo

PY - 2009/1/19

Y1 - 2009/1/19

N2 - Aim: To determine the national practice processes of care and outcomes of radiotherapy for hepatocellular carcinoma (HCC) in Korea. Patients and Methods: A national survey of 53 institutions nationwide was conducted by requesting data on their experience of radiotherapy for HCC. Among them, 10 institutions were selected for performing more detailed analysis, based on the radiotherapy experience of at least five HCC patients between 2004 and 2005. Results: This study covered the treatment of 398 HCC patients for 2 years. Most patients (78%) were in stage III or IV. Radiotherapy was chosen after the failure of other treatments, most frequently transarterial chemoembolization. Radiotherapy was performed predominantly using the three-dimensional conformal technique (3D-CRT, 81.9%) mostly with a total dose of ≥45Gy. In 9.3% of the patients, radiotherapy was performed using radiosurgery. In a biologically effective dose (BED) with 10Gy of α/β, 4.2-124.3Gy 10 was delivered. The median survival time was 12 months, and the 2-year overall survival rate was 27.9%. A tumour size <5 cm, a negative lymph node and BED >53.1Gy 10 were shown by multivariate analysis to be significant factors for a better prognosis. In a subset analysis for the 326 patients treated with 3D-CRT, better liver function with Child-Pugh class A was shown to be an additional factor for a better prognosis. Conclusions: Radiotherapy has been used to treat advanced HCC in various modes, but mostly as a salvage treatment. Although this study was retrospective, it indicates that radiotherapy is a quite effective modality for HCC patients.

AB - Aim: To determine the national practice processes of care and outcomes of radiotherapy for hepatocellular carcinoma (HCC) in Korea. Patients and Methods: A national survey of 53 institutions nationwide was conducted by requesting data on their experience of radiotherapy for HCC. Among them, 10 institutions were selected for performing more detailed analysis, based on the radiotherapy experience of at least five HCC patients between 2004 and 2005. Results: This study covered the treatment of 398 HCC patients for 2 years. Most patients (78%) were in stage III or IV. Radiotherapy was chosen after the failure of other treatments, most frequently transarterial chemoembolization. Radiotherapy was performed predominantly using the three-dimensional conformal technique (3D-CRT, 81.9%) mostly with a total dose of ≥45Gy. In 9.3% of the patients, radiotherapy was performed using radiosurgery. In a biologically effective dose (BED) with 10Gy of α/β, 4.2-124.3Gy 10 was delivered. The median survival time was 12 months, and the 2-year overall survival rate was 27.9%. A tumour size <5 cm, a negative lymph node and BED >53.1Gy 10 were shown by multivariate analysis to be significant factors for a better prognosis. In a subset analysis for the 326 patients treated with 3D-CRT, better liver function with Child-Pugh class A was shown to be an additional factor for a better prognosis. Conclusions: Radiotherapy has been used to treat advanced HCC in various modes, but mostly as a salvage treatment. Although this study was retrospective, it indicates that radiotherapy is a quite effective modality for HCC patients.

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