A multicenter study on extramammary Paget's disease in Korea

Seok Jong Lee, Yoon Seok Choe, Hong Dae Jung, Sung Ku Ahn, Young Chang Cha, Kwang Hyun Cho, Hae Young Choi, Kee Yang Chung, Chang Hun Huh, Il Hwan Kim, Ki Ho Kim, Moon Bum Kim, Myung Hwa Kim, You Chan Kim, Jee Bum Lee, Mi Woo Lee, Min Geol Lee, Weon Ju Lee, Dong Hoon Shin, Jeong Hyun ShinKee Suck Suh, Young Ho Won

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29 Citations (Scopus)

Abstract

Background There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. Results As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). Conclusions In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.

Original languageEnglish
Pages (from-to)508-515
Number of pages8
JournalInternational Journal of Dermatology
Volume50
Issue number5
DOIs
Publication statusPublished - 2011 May 1

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Extramammary Paget's Disease
Korea
Multicenter Studies
Mohs Surgery
Neoplasms
Population
Recurrence
Rectum
Stomach
Colon
Guidelines
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Lee, S. J., Choe, Y. S., Jung, H. D., Ahn, S. K., Cha, Y. C., Cho, K. H., ... Won, Y. H. (2011). A multicenter study on extramammary Paget's disease in Korea. International Journal of Dermatology, 50(5), 508-515. https://doi.org/10.1111/j.1365-4632.2010.04661.x
Lee, Seok Jong ; Choe, Yoon Seok ; Jung, Hong Dae ; Ahn, Sung Ku ; Cha, Young Chang ; Cho, Kwang Hyun ; Choi, Hae Young ; Chung, Kee Yang ; Huh, Chang Hun ; Kim, Il Hwan ; Kim, Ki Ho ; Kim, Moon Bum ; Kim, Myung Hwa ; Kim, You Chan ; Lee, Jee Bum ; Lee, Mi Woo ; Lee, Min Geol ; Lee, Weon Ju ; Shin, Dong Hoon ; Shin, Jeong Hyun ; Suh, Kee Suck ; Won, Young Ho. / A multicenter study on extramammary Paget's disease in Korea. In: International Journal of Dermatology. 2011 ; Vol. 50, No. 5. pp. 508-515.
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title = "A multicenter study on extramammary Paget's disease in Korea",
abstract = "Background There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. Results As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4{\%}), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58{\%}) underwent conventional excisions, and 22 (11.4{\%}) had Mohs surgery. Follow-up data for periods of 3-180months were available for 147 patients; these data indicated that 42 patients (28.6{\%}) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5{\%}) than patients who underwent conventional excision (33.3{\%}). Conclusions In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4{\%}) was higher than that observed in other Asian studies.",
author = "Lee, {Seok Jong} and Choe, {Yoon Seok} and Jung, {Hong Dae} and Ahn, {Sung Ku} and Cha, {Young Chang} and Cho, {Kwang Hyun} and Choi, {Hae Young} and Chung, {Kee Yang} and Huh, {Chang Hun} and Kim, {Il Hwan} and Kim, {Ki Ho} and Kim, {Moon Bum} and Kim, {Myung Hwa} and Kim, {You Chan} and Lee, {Jee Bum} and Lee, {Mi Woo} and Lee, {Min Geol} and Lee, {Weon Ju} and Shin, {Dong Hoon} and Shin, {Jeong Hyun} and Suh, {Kee Suck} and Won, {Young Ho}",
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Lee, SJ, Choe, YS, Jung, HD, Ahn, SK, Cha, YC, Cho, KH, Choi, HY, Chung, KY, Huh, CH, Kim, IH, Kim, KH, Kim, MB, Kim, MH, Kim, YC, Lee, JB, Lee, MW, Lee, MG, Lee, WJ, Shin, DH, Shin, JH, Suh, KS & Won, YH 2011, 'A multicenter study on extramammary Paget's disease in Korea', International Journal of Dermatology, vol. 50, no. 5, pp. 508-515. https://doi.org/10.1111/j.1365-4632.2010.04661.x

A multicenter study on extramammary Paget's disease in Korea. / Lee, Seok Jong; Choe, Yoon Seok; Jung, Hong Dae; Ahn, Sung Ku; Cha, Young Chang; Cho, Kwang Hyun; Choi, Hae Young; Chung, Kee Yang; Huh, Chang Hun; Kim, Il Hwan; Kim, Ki Ho; Kim, Moon Bum; Kim, Myung Hwa; Kim, You Chan; Lee, Jee Bum; Lee, Mi Woo; Lee, Min Geol; Lee, Weon Ju; Shin, Dong Hoon; Shin, Jeong Hyun; Suh, Kee Suck; Won, Young Ho.

In: International Journal of Dermatology, Vol. 50, No. 5, 01.05.2011, p. 508-515.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A multicenter study on extramammary Paget's disease in Korea

AU - Lee, Seok Jong

AU - Choe, Yoon Seok

AU - Jung, Hong Dae

AU - Ahn, Sung Ku

AU - Cha, Young Chang

AU - Cho, Kwang Hyun

AU - Choi, Hae Young

AU - Chung, Kee Yang

AU - Huh, Chang Hun

AU - Kim, Il Hwan

AU - Kim, Ki Ho

AU - Kim, Moon Bum

AU - Kim, Myung Hwa

AU - Kim, You Chan

AU - Lee, Jee Bum

AU - Lee, Mi Woo

AU - Lee, Min Geol

AU - Lee, Weon Ju

AU - Shin, Dong Hoon

AU - Shin, Jeong Hyun

AU - Suh, Kee Suck

AU - Won, Young Ho

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Background There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. Results As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). Conclusions In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.

AB - Background There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. Results As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). Conclusions In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.

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JO - International Journal of Dermatology

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