Abstract
Background There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. Results As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). Conclusions In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
| Original language | English |
|---|---|
| Pages (from-to) | 508-515 |
| Number of pages | 8 |
| Journal | International Journal of Dermatology |
| Volume | 50 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2011 May 1 |
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All Science Journal Classification (ASJC) codes
- Dermatology
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A multicenter study on extramammary Paget's disease in Korea. / Lee, Seok Jong; Choe, Yoon Seok; Jung, Hong Dae; Ahn, Sung Ku; Cha, Young Chang; Cho, Kwang Hyun; Choi, Hae Young; Chung, Kee Yang; Huh, Chang Hun; Kim, Il Hwan; Kim, Ki Ho; Kim, Moon Bum; Kim, Myung Hwa; Kim, You Chan; Lee, Jee Bum; Lee, Mi Woo; Lee, Min Geol; Lee, Weon Ju; Shin, Dong Hoon; Shin, Jeong Hyun; Suh, Kee Suck; Won, Young Ho.
In: International Journal of Dermatology, Vol. 50, No. 5, 01.05.2011, p. 508-515.Research output: Contribution to journal › Article
TY - JOUR
T1 - A multicenter study on extramammary Paget's disease in Korea
AU - Lee, Seok Jong
AU - Choe, Yoon Seok
AU - Jung, Hong Dae
AU - Ahn, Sung Ku
AU - Cha, Young Chang
AU - Cho, Kwang Hyun
AU - Choi, Hae Young
AU - Chung, Kee Yang
AU - Huh, Chang Hun
AU - Kim, Il Hwan
AU - Kim, Ki Ho
AU - Kim, Moon Bum
AU - Kim, Myung Hwa
AU - Kim, You Chan
AU - Lee, Jee Bum
AU - Lee, Mi Woo
AU - Lee, Min Geol
AU - Lee, Weon Ju
AU - Shin, Dong Hoon
AU - Shin, Jeong Hyun
AU - Suh, Kee Suck
AU - Won, Young Ho
PY - 2011/5/1
Y1 - 2011/5/1
N2 - Background There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. Results As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). Conclusions In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
AB - Background There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. Results As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). Conclusions In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
UR - http://www.scopus.com/inward/record.url?scp=79955010751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955010751&partnerID=8YFLogxK
U2 - 10.1111/j.1365-4632.2010.04661.x
DO - 10.1111/j.1365-4632.2010.04661.x
M3 - Article
C2 - 21506963
AN - SCOPUS:79955010751
VL - 50
SP - 508
EP - 515
JO - International Journal of Dermatology
JF - International Journal of Dermatology
SN - 0011-9059
IS - 5
ER -