A multicentre cohort study of acute heart failure syndromes in Korea: Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry

Sang Eun Lee, Hyun Jai Cho, Hae Young Lee, Han Mo Yang, Jin Oh Choi, Eun Seok Jeon, Min Seok Kim, Jae Joong Kim, Kyung Kuk Hwang, Shung Chull Chae, Suk Min Seo, Sang Hong Baek, Seok Min Kang, Il Young Oh, Dong Ju Choi, Byung Su Yoo, Youngkeun Ahn, Hyun Young Park, Myeong Chan Cho, Byung Hee Oh

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Abstract

Aims The Korean Acute Heart Failure registry (KorAHF) aims to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute heart failure syndrome (AHFS) in Korea. Methods and results This is a prospective observational multicentre cohort study funded by the Korea National Institute of Health. Patients hospitalized for AHFS in 10 tertiary university hospitals across the country have been consecutively enrolled since March 2011. The study is expected to complete the scheduled enrolment of 5000 patients some time in 2014, and follow-up is planned through 2016. As of April 2012, the interim analysis of 2066 consecutive subjects was performed to understand the baseline characteristics of the population. The mean age was 69 ± 14 years; 55% were male; and 50% were de novo heart failure. The mean left ventricular ejection fraction (LVEF) was 40 ± 18%. Ischaemia was both the leading cause (38%) and the most frequent aggravating factor (26%) of AHFS. ACE inhibitors/ARBs and beta-blockers were prescribed at discharge in 65% and 51% of the patients, respectively. In-hospital mortality was 5.2%, and 0.9% of patients received urgent heart transplantation. Low blood pressure and azotaemia were the most important predictors of in-hospital mortality. The post-discharge 30-day and 180-day all-cause mortality were 1.2% and 9.2%, respectively. Conclusions Our analysis reveals that the prognosis of AHFS in Korea is poor and that there are specific features, including lower blood pressures at admission and lower rates of heart failure related to hypertension, compared with other registries. Adherence to current guidelines should be improved.

Original languageEnglish
Pages (from-to)700-708
Number of pages9
JournalEuropean Journal of Heart Failure
Volume16
Issue number6
DOIs
Publication statusPublished - 2014 Jun

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, S. E., Cho, H. J., Lee, H. Y., Yang, H. M., Choi, J. O., Jeon, E. S., Kim, M. S., Kim, J. J., Hwang, K. K., Chae, S. C., Seo, S. M., Baek, S. H., Kang, S. M., Oh, I. Y., Choi, D. J., Yoo, B. S., Ahn, Y., Park, H. Y., Cho, M. C., & Oh, B. H. (2014). A multicentre cohort study of acute heart failure syndromes in Korea: Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry. European Journal of Heart Failure, 16(6), 700-708. https://doi.org/10.1002/ejhf.91