A multicentre cohort study of acute heart failure syndromes in Korea: Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry

Sang Eun Lee, Hyun Jai Cho, Hae Young Lee, Han Mo Yang, Jin Oh Choi, Eun Seok Jeon, Min Seok Kim, Jae Joong Kim, Kyung Kuk Hwang, Shung Chull Chae, Suk Min Seo, Sang Hong Baek, Seok Min Kang, Il Young Oh, Dong Ju Choi, Byung Su Yoo, Youngkeun Ahn, Hyun Young Park, Myeong Chan Cho, Byung Hee Oh

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Abstract

Aims The Korean Acute Heart Failure registry (KorAHF) aims to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute heart failure syndrome (AHFS) in Korea. Methods and results This is a prospective observational multicentre cohort study funded by the Korea National Institute of Health. Patients hospitalized for AHFS in 10 tertiary university hospitals across the country have been consecutively enrolled since March 2011. The study is expected to complete the scheduled enrolment of 5000 patients some time in 2014, and follow-up is planned through 2016. As of April 2012, the interim analysis of 2066 consecutive subjects was performed to understand the baseline characteristics of the population. The mean age was 69 ± 14 years; 55% were male; and 50% were de novo heart failure. The mean left ventricular ejection fraction (LVEF) was 40 ± 18%. Ischaemia was both the leading cause (38%) and the most frequent aggravating factor (26%) of AHFS. ACE inhibitors/ARBs and beta-blockers were prescribed at discharge in 65% and 51% of the patients, respectively. In-hospital mortality was 5.2%, and 0.9% of patients received urgent heart transplantation. Low blood pressure and azotaemia were the most important predictors of in-hospital mortality. The post-discharge 30-day and 180-day all-cause mortality were 1.2% and 9.2%, respectively. Conclusions Our analysis reveals that the prognosis of AHFS in Korea is poor and that there are specific features, including lower blood pressures at admission and lower rates of heart failure related to hypertension, compared with other registries. Adherence to current guidelines should be improved.

Original languageEnglish
Pages (from-to)700-708
Number of pages9
JournalEuropean Journal of Heart Failure
Volume16
Issue number6
DOIs
Publication statusPublished - 2014 Jun

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Korea
Multicenter Studies
Registries
Cohort Studies
Heart Failure
Hospital Mortality
Azotemia
National Institutes of Health (U.S.)
Population Characteristics
Heart Transplantation
Angiotensin-Converting Enzyme Inhibitors
Tertiary Care Centers
Stroke Volume
Hypotension
Ischemia
Guidelines
Blood Pressure
Hypertension
Mortality

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, Sang Eun ; Cho, Hyun Jai ; Lee, Hae Young ; Yang, Han Mo ; Choi, Jin Oh ; Jeon, Eun Seok ; Kim, Min Seok ; Kim, Jae Joong ; Hwang, Kyung Kuk ; Chae, Shung Chull ; Seo, Suk Min ; Baek, Sang Hong ; Kang, Seok Min ; Oh, Il Young ; Choi, Dong Ju ; Yoo, Byung Su ; Ahn, Youngkeun ; Park, Hyun Young ; Cho, Myeong Chan ; Oh, Byung Hee. / A multicentre cohort study of acute heart failure syndromes in Korea : Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry. In: European Journal of Heart Failure. 2014 ; Vol. 16, No. 6. pp. 700-708.
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title = "A multicentre cohort study of acute heart failure syndromes in Korea: Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry",
abstract = "Aims The Korean Acute Heart Failure registry (KorAHF) aims to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute heart failure syndrome (AHFS) in Korea. Methods and results This is a prospective observational multicentre cohort study funded by the Korea National Institute of Health. Patients hospitalized for AHFS in 10 tertiary university hospitals across the country have been consecutively enrolled since March 2011. The study is expected to complete the scheduled enrolment of 5000 patients some time in 2014, and follow-up is planned through 2016. As of April 2012, the interim analysis of 2066 consecutive subjects was performed to understand the baseline characteristics of the population. The mean age was 69 ± 14 years; 55{\%} were male; and 50{\%} were de novo heart failure. The mean left ventricular ejection fraction (LVEF) was 40 ± 18{\%}. Ischaemia was both the leading cause (38{\%}) and the most frequent aggravating factor (26{\%}) of AHFS. ACE inhibitors/ARBs and beta-blockers were prescribed at discharge in 65{\%} and 51{\%} of the patients, respectively. In-hospital mortality was 5.2{\%}, and 0.9{\%} of patients received urgent heart transplantation. Low blood pressure and azotaemia were the most important predictors of in-hospital mortality. The post-discharge 30-day and 180-day all-cause mortality were 1.2{\%} and 9.2{\%}, respectively. Conclusions Our analysis reveals that the prognosis of AHFS in Korea is poor and that there are specific features, including lower blood pressures at admission and lower rates of heart failure related to hypertension, compared with other registries. Adherence to current guidelines should be improved.",
author = "Lee, {Sang Eun} and Cho, {Hyun Jai} and Lee, {Hae Young} and Yang, {Han Mo} and Choi, {Jin Oh} and Jeon, {Eun Seok} and Kim, {Min Seok} and Kim, {Jae Joong} and Hwang, {Kyung Kuk} and Chae, {Shung Chull} and Seo, {Suk Min} and Baek, {Sang Hong} and Kang, {Seok Min} and Oh, {Il Young} and Choi, {Dong Ju} and Yoo, {Byung Su} and Youngkeun Ahn and Park, {Hyun Young} and Cho, {Myeong Chan} and Oh, {Byung Hee}",
year = "2014",
month = "6",
doi = "10.1002/ejhf.91",
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journal = "European Journal of Heart Failure",
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Lee, SE, Cho, HJ, Lee, HY, Yang, HM, Choi, JO, Jeon, ES, Kim, MS, Kim, JJ, Hwang, KK, Chae, SC, Seo, SM, Baek, SH, Kang, SM, Oh, IY, Choi, DJ, Yoo, BS, Ahn, Y, Park, HY, Cho, MC & Oh, BH 2014, 'A multicentre cohort study of acute heart failure syndromes in Korea: Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry', European Journal of Heart Failure, vol. 16, no. 6, pp. 700-708. https://doi.org/10.1002/ejhf.91

A multicentre cohort study of acute heart failure syndromes in Korea : Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry. / Lee, Sang Eun; Cho, Hyun Jai; Lee, Hae Young; Yang, Han Mo; Choi, Jin Oh; Jeon, Eun Seok; Kim, Min Seok; Kim, Jae Joong; Hwang, Kyung Kuk; Chae, Shung Chull; Seo, Suk Min; Baek, Sang Hong; Kang, Seok Min; Oh, Il Young; Choi, Dong Ju; Yoo, Byung Su; Ahn, Youngkeun; Park, Hyun Young; Cho, Myeong Chan; Oh, Byung Hee.

In: European Journal of Heart Failure, Vol. 16, No. 6, 06.2014, p. 700-708.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A multicentre cohort study of acute heart failure syndromes in Korea

T2 - Rationale, design, and interim observations of the Korean Acute Heart Failure (KorAHF) registry

AU - Lee, Sang Eun

AU - Cho, Hyun Jai

AU - Lee, Hae Young

AU - Yang, Han Mo

AU - Choi, Jin Oh

AU - Jeon, Eun Seok

AU - Kim, Min Seok

AU - Kim, Jae Joong

AU - Hwang, Kyung Kuk

AU - Chae, Shung Chull

AU - Seo, Suk Min

AU - Baek, Sang Hong

AU - Kang, Seok Min

AU - Oh, Il Young

AU - Choi, Dong Ju

AU - Yoo, Byung Su

AU - Ahn, Youngkeun

AU - Park, Hyun Young

AU - Cho, Myeong Chan

AU - Oh, Byung Hee

PY - 2014/6

Y1 - 2014/6

N2 - Aims The Korean Acute Heart Failure registry (KorAHF) aims to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute heart failure syndrome (AHFS) in Korea. Methods and results This is a prospective observational multicentre cohort study funded by the Korea National Institute of Health. Patients hospitalized for AHFS in 10 tertiary university hospitals across the country have been consecutively enrolled since March 2011. The study is expected to complete the scheduled enrolment of 5000 patients some time in 2014, and follow-up is planned through 2016. As of April 2012, the interim analysis of 2066 consecutive subjects was performed to understand the baseline characteristics of the population. The mean age was 69 ± 14 years; 55% were male; and 50% were de novo heart failure. The mean left ventricular ejection fraction (LVEF) was 40 ± 18%. Ischaemia was both the leading cause (38%) and the most frequent aggravating factor (26%) of AHFS. ACE inhibitors/ARBs and beta-blockers were prescribed at discharge in 65% and 51% of the patients, respectively. In-hospital mortality was 5.2%, and 0.9% of patients received urgent heart transplantation. Low blood pressure and azotaemia were the most important predictors of in-hospital mortality. The post-discharge 30-day and 180-day all-cause mortality were 1.2% and 9.2%, respectively. Conclusions Our analysis reveals that the prognosis of AHFS in Korea is poor and that there are specific features, including lower blood pressures at admission and lower rates of heart failure related to hypertension, compared with other registries. Adherence to current guidelines should be improved.

AB - Aims The Korean Acute Heart Failure registry (KorAHF) aims to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute heart failure syndrome (AHFS) in Korea. Methods and results This is a prospective observational multicentre cohort study funded by the Korea National Institute of Health. Patients hospitalized for AHFS in 10 tertiary university hospitals across the country have been consecutively enrolled since March 2011. The study is expected to complete the scheduled enrolment of 5000 patients some time in 2014, and follow-up is planned through 2016. As of April 2012, the interim analysis of 2066 consecutive subjects was performed to understand the baseline characteristics of the population. The mean age was 69 ± 14 years; 55% were male; and 50% were de novo heart failure. The mean left ventricular ejection fraction (LVEF) was 40 ± 18%. Ischaemia was both the leading cause (38%) and the most frequent aggravating factor (26%) of AHFS. ACE inhibitors/ARBs and beta-blockers were prescribed at discharge in 65% and 51% of the patients, respectively. In-hospital mortality was 5.2%, and 0.9% of patients received urgent heart transplantation. Low blood pressure and azotaemia were the most important predictors of in-hospital mortality. The post-discharge 30-day and 180-day all-cause mortality were 1.2% and 9.2%, respectively. Conclusions Our analysis reveals that the prognosis of AHFS in Korea is poor and that there are specific features, including lower blood pressures at admission and lower rates of heart failure related to hypertension, compared with other registries. Adherence to current guidelines should be improved.

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