A nationwide retrospective study of opioid management patterns in 2,468 patients with spinal pain in Korea

Sung Soo Chung, Chun Kun Park, Kyu Jung Cho, Kyoung Hyo Choi, Jin Hyok Kim, Sung Bum Kim, Sung Uk Kuh, Jae Chul Lee, Jae Hyup Lee, Kyu Yeol Lee, Sun Ho Lee, Seong Hwan Moon, Si Young Park, Jae Hang Shim, Byung Chul Son, Myung Ha Yoon, Hye Jeong Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Study Design: Retrospective patient data collection and investigator survey. Purpose: To investigate patterns of opioid treatment for pain caused by spinal disorders in Korea. Overview of Literature: Opioid analgesic prescription and adequacy of consumption measures in Korea have markedly increased in the past decade, suggesting changing patterns in pain management practice; however, there is lack of integrated data specific to Korean population. Methods: Patient data were collected from medical records at 34 university hospitals in Korea. Outpatients receiving opioids for pain caused by spinal disorders were included in the study. Treatment patterns, including opioid types, doses, treatment duration, outcomes, and adverse drug reactions (ADRs), were evaluated. Investigators were interviewed on their perceptions of opioid use for spinal disorders. Results: Among 2,468 analyzed cases, spinal stenosis (42.8%) was the most common presentation, followed by disc herniation (24.2%) and vertebral fracture (17.5%). In addition, a greater proportion of patients experienced severe pain (73.9%) rather than moderate (19.9%) or mild (0.7%) pain. Oxycodone (51.9%) and fentanyl (50.8%) were the most frequently prescribed opioids; most patients were prescribed relatively low doses. The median duration of opioid treatment was 84 days. Pain relief was superior in patients with longer treatment duration (≥2 months) or with nociceptive pain than in those with shorter treatment duration or with neuropathic or mixed-type pain. ADRs were observed in 8.6% of cases. According to the investigators' survey, "excellent analgesic effect" was a perceived advantage of opioids, while safety concerns were a disadvantage. Conclusions: Opioid usage patterns in patients with spinal disorders are in alignment with international guidelines for spinal pain management. Future prospective studies may address the suitability of opioids for spinal pain treatment by using appropriate objective measurement tools.

Original languageEnglish
Pages (from-to)1122-1131
Number of pages10
JournalAsian Spine Journal
Volume10
Issue number6
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Korea
Opioid Analgesics
Retrospective Studies
Pain
Research Personnel
Pain Management
Drug-Related Side Effects and Adverse Reactions
Therapeutics
Oxycodone
Nociceptive Pain
Spinal Stenosis
Fentanyl
Medical Records
Prescriptions
Analgesics
Outpatients
Prospective Studies
Guidelines
Safety

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Chung, S. S., Park, C. K., Cho, K. J., Choi, K. H., Kim, J. H., Kim, S. B., ... Park, H. J. (2016). A nationwide retrospective study of opioid management patterns in 2,468 patients with spinal pain in Korea. Asian Spine Journal, 10(6), 1122-1131. https://doi.org/10.4184/asj.2016.10.6.1122
Chung, Sung Soo ; Park, Chun Kun ; Cho, Kyu Jung ; Choi, Kyoung Hyo ; Kim, Jin Hyok ; Kim, Sung Bum ; Kuh, Sung Uk ; Lee, Jae Chul ; Lee, Jae Hyup ; Lee, Kyu Yeol ; Lee, Sun Ho ; Moon, Seong Hwan ; Park, Si Young ; Shim, Jae Hang ; Son, Byung Chul ; Yoon, Myung Ha ; Park, Hye Jeong. / A nationwide retrospective study of opioid management patterns in 2,468 patients with spinal pain in Korea. In: Asian Spine Journal. 2016 ; Vol. 10, No. 6. pp. 1122-1131.
@article{cdae4d28a995404993617d8d2299d832,
title = "A nationwide retrospective study of opioid management patterns in 2,468 patients with spinal pain in Korea",
abstract = "Study Design: Retrospective patient data collection and investigator survey. Purpose: To investigate patterns of opioid treatment for pain caused by spinal disorders in Korea. Overview of Literature: Opioid analgesic prescription and adequacy of consumption measures in Korea have markedly increased in the past decade, suggesting changing patterns in pain management practice; however, there is lack of integrated data specific to Korean population. Methods: Patient data were collected from medical records at 34 university hospitals in Korea. Outpatients receiving opioids for pain caused by spinal disorders were included in the study. Treatment patterns, including opioid types, doses, treatment duration, outcomes, and adverse drug reactions (ADRs), were evaluated. Investigators were interviewed on their perceptions of opioid use for spinal disorders. Results: Among 2,468 analyzed cases, spinal stenosis (42.8{\%}) was the most common presentation, followed by disc herniation (24.2{\%}) and vertebral fracture (17.5{\%}). In addition, a greater proportion of patients experienced severe pain (73.9{\%}) rather than moderate (19.9{\%}) or mild (0.7{\%}) pain. Oxycodone (51.9{\%}) and fentanyl (50.8{\%}) were the most frequently prescribed opioids; most patients were prescribed relatively low doses. The median duration of opioid treatment was 84 days. Pain relief was superior in patients with longer treatment duration (≥2 months) or with nociceptive pain than in those with shorter treatment duration or with neuropathic or mixed-type pain. ADRs were observed in 8.6{\%} of cases. According to the investigators' survey, {"}excellent analgesic effect{"} was a perceived advantage of opioids, while safety concerns were a disadvantage. Conclusions: Opioid usage patterns in patients with spinal disorders are in alignment with international guidelines for spinal pain management. Future prospective studies may address the suitability of opioids for spinal pain treatment by using appropriate objective measurement tools.",
author = "Chung, {Sung Soo} and Park, {Chun Kun} and Cho, {Kyu Jung} and Choi, {Kyoung Hyo} and Kim, {Jin Hyok} and Kim, {Sung Bum} and Kuh, {Sung Uk} and Lee, {Jae Chul} and Lee, {Jae Hyup} and Lee, {Kyu Yeol} and Lee, {Sun Ho} and Moon, {Seong Hwan} and Park, {Si Young} and Shim, {Jae Hang} and Son, {Byung Chul} and Yoon, {Myung Ha} and Park, {Hye Jeong}",
year = "2016",
month = "1",
day = "1",
doi = "10.4184/asj.2016.10.6.1122",
language = "English",
volume = "10",
pages = "1122--1131",
journal = "Asian Spine Journal",
issn = "1976-1902",
publisher = "Korean Society of Spine Surgery",
number = "6",

}

Chung, SS, Park, CK, Cho, KJ, Choi, KH, Kim, JH, Kim, SB, Kuh, SU, Lee, JC, Lee, JH, Lee, KY, Lee, SH, Moon, SH, Park, SY, Shim, JH, Son, BC, Yoon, MH & Park, HJ 2016, 'A nationwide retrospective study of opioid management patterns in 2,468 patients with spinal pain in Korea', Asian Spine Journal, vol. 10, no. 6, pp. 1122-1131. https://doi.org/10.4184/asj.2016.10.6.1122

A nationwide retrospective study of opioid management patterns in 2,468 patients with spinal pain in Korea. / Chung, Sung Soo; Park, Chun Kun; Cho, Kyu Jung; Choi, Kyoung Hyo; Kim, Jin Hyok; Kim, Sung Bum; Kuh, Sung Uk; Lee, Jae Chul; Lee, Jae Hyup; Lee, Kyu Yeol; Lee, Sun Ho; Moon, Seong Hwan; Park, Si Young; Shim, Jae Hang; Son, Byung Chul; Yoon, Myung Ha; Park, Hye Jeong.

In: Asian Spine Journal, Vol. 10, No. 6, 01.01.2016, p. 1122-1131.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A nationwide retrospective study of opioid management patterns in 2,468 patients with spinal pain in Korea

AU - Chung, Sung Soo

AU - Park, Chun Kun

AU - Cho, Kyu Jung

AU - Choi, Kyoung Hyo

AU - Kim, Jin Hyok

AU - Kim, Sung Bum

AU - Kuh, Sung Uk

AU - Lee, Jae Chul

AU - Lee, Jae Hyup

AU - Lee, Kyu Yeol

AU - Lee, Sun Ho

AU - Moon, Seong Hwan

AU - Park, Si Young

AU - Shim, Jae Hang

AU - Son, Byung Chul

AU - Yoon, Myung Ha

AU - Park, Hye Jeong

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Study Design: Retrospective patient data collection and investigator survey. Purpose: To investigate patterns of opioid treatment for pain caused by spinal disorders in Korea. Overview of Literature: Opioid analgesic prescription and adequacy of consumption measures in Korea have markedly increased in the past decade, suggesting changing patterns in pain management practice; however, there is lack of integrated data specific to Korean population. Methods: Patient data were collected from medical records at 34 university hospitals in Korea. Outpatients receiving opioids for pain caused by spinal disorders were included in the study. Treatment patterns, including opioid types, doses, treatment duration, outcomes, and adverse drug reactions (ADRs), were evaluated. Investigators were interviewed on their perceptions of opioid use for spinal disorders. Results: Among 2,468 analyzed cases, spinal stenosis (42.8%) was the most common presentation, followed by disc herniation (24.2%) and vertebral fracture (17.5%). In addition, a greater proportion of patients experienced severe pain (73.9%) rather than moderate (19.9%) or mild (0.7%) pain. Oxycodone (51.9%) and fentanyl (50.8%) were the most frequently prescribed opioids; most patients were prescribed relatively low doses. The median duration of opioid treatment was 84 days. Pain relief was superior in patients with longer treatment duration (≥2 months) or with nociceptive pain than in those with shorter treatment duration or with neuropathic or mixed-type pain. ADRs were observed in 8.6% of cases. According to the investigators' survey, "excellent analgesic effect" was a perceived advantage of opioids, while safety concerns were a disadvantage. Conclusions: Opioid usage patterns in patients with spinal disorders are in alignment with international guidelines for spinal pain management. Future prospective studies may address the suitability of opioids for spinal pain treatment by using appropriate objective measurement tools.

AB - Study Design: Retrospective patient data collection and investigator survey. Purpose: To investigate patterns of opioid treatment for pain caused by spinal disorders in Korea. Overview of Literature: Opioid analgesic prescription and adequacy of consumption measures in Korea have markedly increased in the past decade, suggesting changing patterns in pain management practice; however, there is lack of integrated data specific to Korean population. Methods: Patient data were collected from medical records at 34 university hospitals in Korea. Outpatients receiving opioids for pain caused by spinal disorders were included in the study. Treatment patterns, including opioid types, doses, treatment duration, outcomes, and adverse drug reactions (ADRs), were evaluated. Investigators were interviewed on their perceptions of opioid use for spinal disorders. Results: Among 2,468 analyzed cases, spinal stenosis (42.8%) was the most common presentation, followed by disc herniation (24.2%) and vertebral fracture (17.5%). In addition, a greater proportion of patients experienced severe pain (73.9%) rather than moderate (19.9%) or mild (0.7%) pain. Oxycodone (51.9%) and fentanyl (50.8%) were the most frequently prescribed opioids; most patients were prescribed relatively low doses. The median duration of opioid treatment was 84 days. Pain relief was superior in patients with longer treatment duration (≥2 months) or with nociceptive pain than in those with shorter treatment duration or with neuropathic or mixed-type pain. ADRs were observed in 8.6% of cases. According to the investigators' survey, "excellent analgesic effect" was a perceived advantage of opioids, while safety concerns were a disadvantage. Conclusions: Opioid usage patterns in patients with spinal disorders are in alignment with international guidelines for spinal pain management. Future prospective studies may address the suitability of opioids for spinal pain treatment by using appropriate objective measurement tools.

UR - http://www.scopus.com/inward/record.url?scp=85008192069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008192069&partnerID=8YFLogxK

U2 - 10.4184/asj.2016.10.6.1122

DO - 10.4184/asj.2016.10.6.1122

M3 - Article

AN - SCOPUS:85008192069

VL - 10

SP - 1122

EP - 1131

JO - Asian Spine Journal

JF - Asian Spine Journal

SN - 1976-1902

IS - 6

ER -