A network analysis of 15 O-H 2 O pet reveals deep brain stimulation effects on brain network of Parkinson’s disease

Hae Jeong Park, Bumhee Park, Hae Yu Kim, Maeng Keun Oh, Joong Il Kim, Misun Yoon, Jong Doo Lee, JinWoo Chang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: As Parkinson’s disease (PD) can be considered a network abnormality, the effects of deep brain stimulation (DBS) need to be investigated in the aspect of networks. This study aimed to examine how DBS of the bilateral subthalamic nucleus (STN) affects the motor networks of patients with idiopathic PD during motor performance and to show the feasibility of the network analysis using cross-sectional positron emission tomography (PET) images in DBS studies. Materials and Methods: We obtained [15 O]H 2 O PET images from ten patients with PD during a sequential finger-to-thumb opposition task and during the resting state, with DBS-On and DBS-Off at STN. To identify the alteration of motor networks in PD and their changes due to STN-DBS, we applied independent component analysis (ICA) to all the cross-sectional PET images. We analysed the strength of each component according to DBS effects, task effects and interaction effects. Results: ICA blindly decomposed components of functionally associated distributed clusters, which were comparable to the results of univariate statistical parametric mapping. ICA further revealed that STN-DBS modifies usage-strengths of components corresponding to the basal ganglia-thalamo-cortical circuits in PD patients by increasing the hypoactive basal ganglia and by suppressing the hyperactive cortical motor areas, ventrolateral thalamus and cerebellum. Conclusion: Our results suggest that STN-DBS may affect not only the abnormal local activity, but also alter brain networks in patients with PD. This study also demonstrated the usefulness of ICA for cross-sectional PET data to reveal network modifications due to DBS, which was not observable using the subtraction method.

Original languageEnglish
Pages (from-to)726-736
Number of pages11
JournalYonsei medical journal
Volume56
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1

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Deep Brain Stimulation
Pets
Parkinson Disease
Subthalamic Nucleus
Brain
Positron-Emission Tomography
Basal Ganglia
Cross-Sectional Studies
Ventral Thalamic Nuclei
Thumb
Motor Cortex
Cerebellum
Fingers

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, Hae Jeong ; Park, Bumhee ; Kim, Hae Yu ; Oh, Maeng Keun ; Kim, Joong Il ; Yoon, Misun ; Lee, Jong Doo ; Chang, JinWoo. / A network analysis of 15 O-H 2 O pet reveals deep brain stimulation effects on brain network of Parkinson’s disease In: Yonsei medical journal. 2015 ; Vol. 56, No. 3. pp. 726-736.
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abstract = "Purpose: As Parkinson’s disease (PD) can be considered a network abnormality, the effects of deep brain stimulation (DBS) need to be investigated in the aspect of networks. This study aimed to examine how DBS of the bilateral subthalamic nucleus (STN) affects the motor networks of patients with idiopathic PD during motor performance and to show the feasibility of the network analysis using cross-sectional positron emission tomography (PET) images in DBS studies. Materials and Methods: We obtained [15 O]H 2 O PET images from ten patients with PD during a sequential finger-to-thumb opposition task and during the resting state, with DBS-On and DBS-Off at STN. To identify the alteration of motor networks in PD and their changes due to STN-DBS, we applied independent component analysis (ICA) to all the cross-sectional PET images. We analysed the strength of each component according to DBS effects, task effects and interaction effects. Results: ICA blindly decomposed components of functionally associated distributed clusters, which were comparable to the results of univariate statistical parametric mapping. ICA further revealed that STN-DBS modifies usage-strengths of components corresponding to the basal ganglia-thalamo-cortical circuits in PD patients by increasing the hypoactive basal ganglia and by suppressing the hyperactive cortical motor areas, ventrolateral thalamus and cerebellum. Conclusion: Our results suggest that STN-DBS may affect not only the abnormal local activity, but also alter brain networks in patients with PD. This study also demonstrated the usefulness of ICA for cross-sectional PET data to reveal network modifications due to DBS, which was not observable using the subtraction method.",
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A network analysis of 15 O-H 2 O pet reveals deep brain stimulation effects on brain network of Parkinson’s disease . / Park, Hae Jeong; Park, Bumhee; Kim, Hae Yu; Oh, Maeng Keun; Kim, Joong Il; Yoon, Misun; Lee, Jong Doo; Chang, JinWoo.

In: Yonsei medical journal, Vol. 56, No. 3, 01.01.2015, p. 726-736.

Research output: Contribution to journalArticle

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