A new efficient method for detecting phase singularity in cardiac fibrillation

Young Seon Lee, Jun Seop Song, Minki Hwang, Byounghyun Lim, Boyoung Joung, huinam pak

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background The point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. Computational efficiency is important for detection of PS in clinical electrophysiology. We developed a novel algorithm for highly efficient and robust detection of PS. Methods In contrast to the conventional method, which calculates PS based on the line integral of the phase around a PS point equal to ±2pi; (the Iyer-Gray method), the proposed algorithm (the location-centric method) looks for the phase discontinuity point at which PS actually occurs. We tested the efficiency and robustness of these two methods in a two-dimensional mathematical model of atrial fibrillation (AF), with and without remodeling of ionic currents. Results 1. There was a significant association, in terms of the Hausdorff distance (3.30 ± 0.0 mm), between the PS points measured using the Iyer-Gray and location-centric methods, with almost identical PS trajectories generated by the two methods. 2. For the condition of electrical remodeling of AF (0.3 × I CaL ), the PS points calculated by the two methods were satisfactorily co-localized (with the Hausdorff distance of 1.64±0.09 mm). 3. The proposed location-centric method was substantially more efficient than the Iyer-Gray method, with a 28.6-fold and 28.2-fold shorter run times for the control and remodeling scenarios, respectively. Conclusion We propose a new location-centric method for calculating PS, which is robust and more efficient compared with the conventionally used method.

Original languageEnglish
Article numbere0167567
JournalPloS one
Volume11
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

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Electrophysiology
Computational efficiency
methodology
Rotors
Trajectories
Mathematical models
Atrial Fibrillation
Atrial Remodeling
electrophysiology
rotors
trajectories
Theoretical Models
mathematical models
atrial fibrillation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lee, Young Seon ; Song, Jun Seop ; Hwang, Minki ; Lim, Byounghyun ; Joung, Boyoung ; pak, huinam. / A new efficient method for detecting phase singularity in cardiac fibrillation. In: PloS one. 2016 ; Vol. 11, No. 12.
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A new efficient method for detecting phase singularity in cardiac fibrillation. / Lee, Young Seon; Song, Jun Seop; Hwang, Minki; Lim, Byounghyun; Joung, Boyoung; pak, huinam.

In: PloS one, Vol. 11, No. 12, e0167567, 01.12.2016.

Research output: Contribution to journalArticle

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N2 - Background The point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. Computational efficiency is important for detection of PS in clinical electrophysiology. We developed a novel algorithm for highly efficient and robust detection of PS. Methods In contrast to the conventional method, which calculates PS based on the line integral of the phase around a PS point equal to ±2pi; (the Iyer-Gray method), the proposed algorithm (the location-centric method) looks for the phase discontinuity point at which PS actually occurs. We tested the efficiency and robustness of these two methods in a two-dimensional mathematical model of atrial fibrillation (AF), with and without remodeling of ionic currents. Results 1. There was a significant association, in terms of the Hausdorff distance (3.30 ± 0.0 mm), between the PS points measured using the Iyer-Gray and location-centric methods, with almost identical PS trajectories generated by the two methods. 2. For the condition of electrical remodeling of AF (0.3 × I CaL ), the PS points calculated by the two methods were satisfactorily co-localized (with the Hausdorff distance of 1.64±0.09 mm). 3. The proposed location-centric method was substantially more efficient than the Iyer-Gray method, with a 28.6-fold and 28.2-fold shorter run times for the control and remodeling scenarios, respectively. Conclusion We propose a new location-centric method for calculating PS, which is robust and more efficient compared with the conventionally used method.

AB - Background The point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. Computational efficiency is important for detection of PS in clinical electrophysiology. We developed a novel algorithm for highly efficient and robust detection of PS. Methods In contrast to the conventional method, which calculates PS based on the line integral of the phase around a PS point equal to ±2pi; (the Iyer-Gray method), the proposed algorithm (the location-centric method) looks for the phase discontinuity point at which PS actually occurs. We tested the efficiency and robustness of these two methods in a two-dimensional mathematical model of atrial fibrillation (AF), with and without remodeling of ionic currents. Results 1. There was a significant association, in terms of the Hausdorff distance (3.30 ± 0.0 mm), between the PS points measured using the Iyer-Gray and location-centric methods, with almost identical PS trajectories generated by the two methods. 2. For the condition of electrical remodeling of AF (0.3 × I CaL ), the PS points calculated by the two methods were satisfactorily co-localized (with the Hausdorff distance of 1.64±0.09 mm). 3. The proposed location-centric method was substantially more efficient than the Iyer-Gray method, with a 28.6-fold and 28.2-fold shorter run times for the control and remodeling scenarios, respectively. Conclusion We propose a new location-centric method for calculating PS, which is robust and more efficient compared with the conventionally used method.

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