A new efficient method for detecting phase singularity in cardiac fibrillation

Young Seon Lee, Jun Seop Song, Minki Hwang, Byounghyun Lim, Boyoung Joung, Hui Nam Pak

Research output: Contribution to journalArticle

8 Citations (Scopus)


Background The point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. Computational efficiency is important for detection of PS in clinical electrophysiology. We developed a novel algorithm for highly efficient and robust detection of PS. Methods In contrast to the conventional method, which calculates PS based on the line integral of the phase around a PS point equal to ±2pi; (the Iyer-Gray method), the proposed algorithm (the location-centric method) looks for the phase discontinuity point at which PS actually occurs. We tested the efficiency and robustness of these two methods in a two-dimensional mathematical model of atrial fibrillation (AF), with and without remodeling of ionic currents. Results 1. There was a significant association, in terms of the Hausdorff distance (3.30 ± 0.0 mm), between the PS points measured using the Iyer-Gray and location-centric methods, with almost identical PS trajectories generated by the two methods. 2. For the condition of electrical remodeling of AF (0.3 × ICaL), the PS points calculated by the two methods were satisfactorily co-localized (with the Hausdorff distance of 1.64±0.09 mm). 3. The proposed location-centric method was substantially more efficient than the Iyer-Gray method, with a 28.6-fold and 28.2-fold shorter run times for the control and remodeling scenarios, respectively. Conclusion We propose a new location-centric method for calculating PS, which is robust and more efficient compared with the conventionally used method.

Original languageEnglish
Article numbere0167567
JournalPloS one
Issue number12
Publication statusPublished - 2016 Dec

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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