Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of fungal and herpes virus infections. A new naphthoquinone racemate, rhinacasutone (1) together with seven known compounds, rhinacanthone (2), rhinacanthins C, D, N, Q, and E (3–7), and heliobuphthalmin (8) were isolated from root of R. nasutus. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR and MS data. All the isolated compounds were tested for their antiviral activities against PR8, HRV1B, and CVB3-infected vero cells. Compounds 3–6 exhibited significant antiviral activities with the IC50 value ranging from 0.03 to 23.7 μM in all three infections.
Bibliographical noteFunding Information:
This research was supported by the National Research Foundation of Korea (NRF) [grant number NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Plant Science
- Organic Chemistry