A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts

Hyunji Lee, Youngeun Hong, Quangdon Tran, Hyeonjeong Cho, Minhee Kim, Chaeyeong Kim, So Hee Kwon, Sung Jin Park, Jongsun Park, Jisoo Park

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Background: The efficacy of ginseng, the representative product of Korea, and its chemical effects have been well investigated. The ginsenoside RG3 has been reported to exhibit apoptotic, anticancer, and antidepressant-like effects. Methods: In this report, the putative effect of RG3 on several cellular function including cell survival, differentiation, development and aging process were evaluated by monitoring each specific marker. Also, mitochondrial morphology and function were investigated in ultraviolet (UV)-irradiated normal human dermal fibroblast cells. Results: RG3 treatment increased the expression of extracellular matrix proteins, growth-associated immediate-early genes, and cell proliferation genes in UV-irradiated normal human dermal fibroblast cells. And, RG3 also resulted in enhanced expression of antioxidant proteins such as nuclear factor erythroid 2–related factor-2 and heme oxygenase-1. In addition, RG3 affects the morphology of UV-induced mitochondria and plays a role in protecting mitochondrial dysfunction. Conclusioin: RG3 restores mitochondrial adenosine triphosphate (ATP) and membrane potential via its antioxidant effects in skin cells damaged by UV irradiation, leading to an increase in proteins linked with the extracellular matrix, cell proliferation, and antioxidant activity.

Original languageEnglish
Pages (from-to)431-441
Number of pages11
JournalJournal of Ginseng Research
Issue number3
Publication statusPublished - 2019 Jul

Bibliographical note

Funding Information:
This work was financially supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (NRF-2014R1A1A3050752, NRF-2015R1A2A2A01003597, NRF-2016K1A3A1A08953546).

Publisher Copyright:
© 2018

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Complementary and alternative medicine


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