A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts

Hyunji Lee, Youngeun Hong, Quangdon Tran, Hyeonjeong Cho, Minhee Kim, Chaeyeong Kim, So Hee Kwon, Sung Jin Park, Jongsun Park, Jisoo Park

Research output: Contribution to journalArticle

Abstract

Background: The efficacy of ginseng, the representative product of Korea, and its chemical effects have been well investigated. The ginsenoside RG3 has been reported to exhibit apoptotic, anticancer, and antidepressant-like effects. Methods: In this report, the putative effect of RG3 on several cellular function including cell survival, differentiation, development and aging process were evaluated by monitoring each specific marker. Also, mitochondrial morphology and function were investigated in ultraviolet (UV)-irradiated normal human dermal fibroblast cells. Results: RG3 treatment increased the expression of extracellular matrix proteins, growth-associated immediate-early genes, and cell proliferation genes in UV-irradiated normal human dermal fibroblast cells. And, RG3 also resulted in enhanced expression of antioxidant proteins such as nuclear factor erythroid 2–related factor-2 and heme oxygenase-1. In addition, RG3 affects the morphology of UV-induced mitochondria and plays a role in protecting mitochondrial dysfunction. Conclusioin: RG3 restores mitochondrial adenosine triphosphate (ATP) and membrane potential via its antioxidant effects in skin cells damaged by UV irradiation, leading to an increase in proteins linked with the extracellular matrix, cell proliferation, and antioxidant activity.

Original languageEnglish
JournalJournal of Ginseng Research
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Ginsenosides
Mitochondria
Fibroblasts
Antioxidants
Cells
Cell proliferation
Skin
Genes
Cell Proliferation
Panax
Heme Oxygenase-1
Immediate-Early Genes
Cell Aging
Extracellular Matrix Proteins
Korea
Membrane Potentials
Antidepressive Agents
Extracellular Matrix
Cell Differentiation
Cell Survival

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Complementary and alternative medicine

Cite this

Lee, Hyunji ; Hong, Youngeun ; Tran, Quangdon ; Cho, Hyeonjeong ; Kim, Minhee ; Kim, Chaeyeong ; Kwon, So Hee ; Park, Sung Jin ; Park, Jongsun ; Park, Jisoo. / A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts. In: Journal of Ginseng Research. 2018.
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A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts. / Lee, Hyunji; Hong, Youngeun; Tran, Quangdon; Cho, Hyeonjeong; Kim, Minhee; Kim, Chaeyeong; Kwon, So Hee; Park, Sung Jin; Park, Jongsun; Park, Jisoo.

In: Journal of Ginseng Research, 01.01.2018.

Research output: Contribution to journalArticle

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AU - Hong, Youngeun

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AU - Cho, Hyeonjeong

AU - Kim, Minhee

AU - Kim, Chaeyeong

AU - Kwon, So Hee

AU - Park, Sung Jin

AU - Park, Jongsun

AU - Park, Jisoo

PY - 2018/1/1

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N2 - Background: The efficacy of ginseng, the representative product of Korea, and its chemical effects have been well investigated. The ginsenoside RG3 has been reported to exhibit apoptotic, anticancer, and antidepressant-like effects. Methods: In this report, the putative effect of RG3 on several cellular function including cell survival, differentiation, development and aging process were evaluated by monitoring each specific marker. Also, mitochondrial morphology and function were investigated in ultraviolet (UV)-irradiated normal human dermal fibroblast cells. Results: RG3 treatment increased the expression of extracellular matrix proteins, growth-associated immediate-early genes, and cell proliferation genes in UV-irradiated normal human dermal fibroblast cells. And, RG3 also resulted in enhanced expression of antioxidant proteins such as nuclear factor erythroid 2–related factor-2 and heme oxygenase-1. In addition, RG3 affects the morphology of UV-induced mitochondria and plays a role in protecting mitochondrial dysfunction. Conclusioin: RG3 restores mitochondrial adenosine triphosphate (ATP) and membrane potential via its antioxidant effects in skin cells damaged by UV irradiation, leading to an increase in proteins linked with the extracellular matrix, cell proliferation, and antioxidant activity.

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