A new subtype classification of ischemic stroke based on treatment and etiologic mechanism

Sang Won Han, Seo Hyun Kim, Jong Yun Lee, Chong Kyu Chu, Jae Hoon Yang, Ha Young Shin, Hyo Suk Nam, Byung In Lee, Ji Hoe Heo

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119 Citations (Scopus)

Abstract

A new subtype classification of ischemic stroke was developed to reflect recent therapeutic strategies as well as evolving concepts of stroke definitions and mechanisms. In 200 consecutive patients with acute ischemic stroke, the inter-rater reliability and proportion of subtypes of the new classification system were assessed and compared with those of the Trial of ORG 10172 in the Acute Stroke Treatment (TOAST) classification. The most frequent subtype of the new classification was atherothrombosis (n = 80, 40%), followed by stroke of undetermined etiology (n = 54, 27%), small artery disease (n = 33, 16.5%), cardioembolism (n = 26, 13%), and stroke of other determined etiology (n = 7, 3.5%). Three raters agreed to the stroke subtype diagnosis in 165 out of 200 cases and the overall κ value was excellent (κ = 0.82). The new classification system for brain infarction was easy to use and had high inter-rater reliability.

Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalEuropean Neurology
Volume57
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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  • Cite this

    Han, S. W., Kim, S. H., Lee, J. Y., Chu, C. K., Yang, J. H., Shin, H. Y., Nam, H. S., Lee, B. I., & Heo, J. H. (2007). A new subtype classification of ischemic stroke based on treatment and etiologic mechanism. European Neurology, 57(2), 96-102. https://doi.org/10.1159/000098059